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PDB: 730 件
4QAP
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The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1
著者Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P.
登録日2014-05-05
公開日2015-02-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.903 Å)
主引用文献The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop
Int.J.Biochem.Cell Biol., 57, 2014
4QAH
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The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1
著者Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Bi, W.X.
登録日2014-05-05
公開日2014-12-24
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.403 Å)
主引用文献The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop
Int.J.Biochem.Cell Biol., 57C, 2014
4QUM
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Crystal structure of PTPN3 (PTPH1) in complex with a dually phosphorylated MAPK12 peptide
分子名称: Mitogen-activated protein kinase 12, Tyrosine-protein phosphatase non-receptor type 3
著者Chen, K.E, Meng, T.C, Wang, A.H.J.
登録日2014-07-10
公開日2014-12-10
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.516 Å)
主引用文献Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation.
Sci.Signal., 7, 2014
4QUN
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BU of 4qun by Molmil
Crystal structure of the PTPN3 (PTPH1) catalytic domain C842S mutant
分子名称: GLYCEROL, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 3
著者Chen, K.E, Meng, T.C, Wang, A.H.J.
登録日2014-07-11
公開日2014-12-10
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation.
Sci.Signal., 7, 2014
4RDD
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BU of 4rdd by Molmil
Co-crystal structure of SHP2 in complex with a Cefsulodin derivative
分子名称: 1-({(2R)-4-carboxy-2-[(R)-carboxy{[(2R)-2-phenyl-2-sulfoacetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, Tyrosine-protein phosphatase non-receptor type 11
著者Zhang, Z.Y, Yu, Z.H, He, R, Zhang, R.Y.
登録日2014-09-18
公開日2015-07-01
最終更新日2015-12-16
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.
ACS Med Chem Lett, 6, 2015
4RI4
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BU of 4ri4 by Molmil
Crystal structure of PTPN3 (PTPH1) Y676I mutant in complex with vanadate
分子名称: Tyrosine-protein phosphatase non-receptor type 3, VANADATE ION
著者Chen, K.-E, Meng, T.C, Wang, A.H.-J.
登録日2014-10-05
公開日2015-03-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.596 Å)
主引用文献Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
Structure, 23, 2015
4RI5
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BU of 4ri5 by Molmil
Crystal structure of PTPN3 (PTPH1) D811E mutant in complex with metavanadate
分子名称: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 3, oxido(dioxo)vanadium
著者Chen, K.-E, Meng, T.C, Wang, A.H.-J.
登録日2014-10-05
公開日2015-03-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.26 Å)
主引用文献Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
Structure, 23, 2015
4RH5
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BU of 4rh5 by Molmil
Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 peptide
分子名称: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3
著者Chen, K.-E, Meng, T.C, Wang, A.H.-J.
登録日2014-10-01
公開日2015-03-11
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
Structure, 23, 2015
4RH9
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Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with Eps15 pTyr849 peptide
分子名称: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3
著者Chen, K.-E, Meng, T.C, Wang, A.H.-J.
登録日2014-10-01
公開日2015-03-11
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.598 Å)
主引用文献Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
Structure, 23, 2015
4RHG
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BU of 4rhg by Molmil
Crystal structure of PTPN3 (PTPH1) D811E, C842S mutant in complex with Eps15 pTyr849 peptide
分子名称: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3
著者Chen, K.-E, Meng, T.C, Wang, A.H.-J.
登録日2014-10-02
公開日2015-03-11
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.581 Å)
主引用文献Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
Structure, 23, 2015
3QCF
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BU of 3qcf by Molmil
Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxylic acid via co-crystallization
分子名称: 3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxylic acid, Receptor-type tyrosine-protein phosphatase gamma, SULFATE ION
著者Sheriff, S.
登録日2011-01-16
公開日2011-12-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop
J.Med.Chem., 54, 2011
3QCC
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BU of 3qcc by Molmil
Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, orthorhombic crystal form
分子名称: Receptor-type tyrosine-protein phosphatase gamma, VANADATE ION
著者Sheriff, S.
登録日2011-01-16
公開日2011-12-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop
J.Med.Chem., 54, 2011
3QCG
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BU of 3qcg by Molmil
Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 3-[(3-bromo-4-chlorobenzyl)sulfanyl]thiophene-2-carboxylic acid
分子名称: 3-[(3-bromo-4-chlorobenzyl)sulfanyl]thiophene-2-carboxylic acid, ACETIC ACID, Receptor-type tyrosine-protein phosphatase gamma
著者Sheriff, S.
登録日2011-01-16
公開日2011-12-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop
J.Med.Chem., 54, 2011
3QKQ
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BU of 3qkq by Molmil
Protein Tyrosine Phosphatase 1B - W179F mutant bound with vanadate
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ...
著者Brandao, T.A.S, Johnson, S.J, Hengge, A.C.
登録日2011-02-01
公開日2012-08-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B.
Arch.Biochem.Biophys., 525, 2012
3QCB
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BU of 3qcb by Molmil
Human receptor protein tyrosine phosphatase gamma, domain 1, apo
分子名称: Receptor-type tyrosine-protein phosphatase gamma, SULFATE ION
著者Sheriff, S.
登録日2011-01-16
公開日2011-12-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop
J.Med.Chem., 54, 2011
3QCN
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BU of 3qcn by Molmil
Human receptor protein tyrosine phosphatase gamma, domain 1, trigonal crystal form
分子名称: Receptor-type tyrosine-protein phosphatase gamma
著者Sheriff, S.
登録日2011-01-16
公開日2011-12-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop
J.Med.Chem., 54, 2011
3QCJ
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BU of 3qcj by Molmil
Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 5-[({3-[(3,4-dichlorobenzyl)sulfanyl]thiophen-2-yl}carbonyl)sulfamoyl]-2-methoxybenzoic acid
分子名称: 5-[({3-[(3,4-dichlorobenzyl)sulfanyl]thiophen-2-yl}carbonyl)sulfamoyl]-2-methoxybenzoic acid, Receptor-type tyrosine-protein phosphatase gamma
著者Sheriff, S.
登録日2011-01-16
公開日2011-12-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop
J.Med.Chem., 54, 2011
3S3F
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BU of 3s3f by Molmil
Crystal Structure of the catalytic domain of PTP10D from Drosophila melanogaster with a small molecule inhibitor Vanadate
分子名称: 1,4-BUTANEDIOL, 1-BUTANOL, ISOPROPYL ALCOHOL, ...
著者Madan, L.L, Gopal, B.
登録日2011-05-18
公開日2011-11-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D
Biochemistry, 50, 2011
3S3E
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BU of 3s3e by Molmil
Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster
分子名称: 1,4-BUTANEDIOL, 1-BUTANOL, ISOPROPYL ALCOHOL, ...
著者Madan, L.L, Gopal, B.
登録日2011-05-18
公開日2011-11-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D
Biochemistry, 50, 2011
3S3H
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BU of 3s3h by Molmil
Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster with a phosphopeptide substrate GP4
分子名称: 1,4-BUTANEDIOL, 1-BUTANOL, Tyrosine-protein phosphatase 10D, ...
著者Madan, L.L, Gopal, B.
登録日2011-05-18
公開日2011-11-02
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D
Biochemistry, 50, 2011
3RO1
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BU of 3ro1 by Molmil
Crystal structure of the complex of the archaeal sulfolobus PTP-fold phosphatase with terpyridine platinum(II)
分子名称: 2,2':6',2''-TERPYRIDINE PLATINUM(II) Chloride, protein tyrosine phosphatase
著者Lo, Y.-C, Wang, A.H.-J.
登録日2011-04-25
公開日2011-10-05
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Terpyridine platinum(II) complexes inhibit cysteine proteases by binding to active-site cysteine.
J.Biomol.Struct.Dyn., 29, 2011
3SR9
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Crystal structure of mouse PTPsigma
分子名称: Receptor-type tyrosine-protein phosphatase S
著者Wang, J, Hou, L, Li, J, Ding, J.
登録日2011-07-07
公開日2012-05-30
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma
Acta Biochim.Biophys.Sin., 43, 2011
3QKP
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Protein Tyrosine Phosphatase 1B - Apo W179F mutant with open WPD-loop
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1
著者Brandao, T.A.S, Johnson, S.J, Hengge, A.C.
登録日2011-02-01
公開日2012-08-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B.
Arch.Biochem.Biophys., 525, 2012
3S3K
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BU of 3s3k by Molmil
Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster with a small molecular inhibitor para-NitroCatechol Sulphate
分子名称: N,4-DIHYDROXY-N-OXO-3-(SULFOOXY)BENZENAMINIUM, Tyrosine-protein phosphatase 10D
著者Madan, L.L, Gopal, B.
登録日2011-05-18
公開日2011-11-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D
Biochemistry, 50, 2011
3S4O
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Protein Tyrosine Phosphatase (putative) from Leishmania major
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Protein tyrosine phosphatase-like protein, THIOSULFATE
著者Merritt, E.A, Arakaki, T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP), Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2011-05-19
公開日2011-06-15
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Protein Tyrosine Phosphatase from Leishmania major
To be Published

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