Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster with a small molecular inhibitor para-NitroCatechol Sulphate

Summary for 3S3K

Related3S3E 3S3F 3S3H
DescriptorTyrosine-protein phosphatase 10D, N,4-DIHYDROXY-N-OXO-3-(SULFOOXY)BENZENAMINIUM (3 entities in total)
Functional Keywordsdifferentiation, neurogenesis, signal transduction, developmental protein, hydrolase, protein phosphatase, protein tyrosine phosphatase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceDrosophila melanogaster (Fruit fly)
Cellular locationMembrane; Single-pass type I membrane protein P35992
Total number of polymer chains2
Total molecular weight72126.44
Madan, L.L.,Gopal, B. (deposition date: 2011-05-18, release date: 2011-11-02, Last modification date: 2013-07-03)
Primary citation
Madan, L.L.,Gopal, B.
Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D
Biochemistry, 50:10114-10125, 2011
PubMed: 22007620 (PDB entries with the same primary citation)
DOI: 10.1021/bi201092q
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.264161.9%7.8%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-07-29