3QCJ

Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 5-[({3-[(3,4-dichlorobenzyl)sulfanyl]thiophen-2-yl}carbonyl)sulfamoyl]-2-methoxybenzoic acid

Summary for 3QCJ

Entry DOI	10.2210/pdb3qcj/pdb
Related	3QCB 3QCC 3QCD 3QCE 3QCF 3QCG 3QCH 3QCI 3QCK 3QCL 3QCM 3QCN
Descriptor	Receptor-type tyrosine-protein phosphatase gamma, 5-[({3-[(3,4-dichlorobenzyl)sulfanyl]thiophen-2-yl}carbonyl)sulfamoyl]-2-methoxybenzoic acid (3 entities in total)
Functional Keywords	tyrosine receptor phosphatase, twisted mixed beta-sheets flanked by {alpha}-helices, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein (Probable): P23470
Total number of polymer chains	1
Total formula weight	36240.01
Authors	Sheriff, S. (deposition date: 2011-01-16, release date: 2011-12-28, Last modification date: 2023-09-13)
Primary citation	Sheriff, S.,Beno, B.R.,Zhai, W.,Kostich, W.A.,McDonnell, P.A.,Kish, K.,Goldfarb, V.,Gao, M.,Kiefer, S.E.,Yanchunas, J.,Huang, Y.,Shi, S.,Zhu, S.,Dzierba, C.,Bronson, J.,Macor, J.E.,Appiah, K.K.,Westphal, R.S.,O'Connell, J.,Gerritz, S.W. Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54:6548-6562, 2011 Cited by PubMed: 21882820 DOI: 10.1021/jm2003766 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.26 Å)

Structure validation