3QKP

Protein Tyrosine Phosphatase 1B - Apo W179F mutant with open WPD-loop

Summary for 3QKP

Entry DOI	10.2210/pdb3qkp/pdb
Related	2CM2 3F99 3QKN 3QKO 3QKQ
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... (4 entities in total)
Functional Keywords	hydrolase, p-loop, wpd-loop, protein phosphatase, egfr receptor, phosphoprotein
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains	1
Total formula weight	37632.94
Authors	Brandao, T.A.S.,Johnson, S.J.,Hengge, A.C. (deposition date: 2011-02-01, release date: 2012-08-08, Last modification date: 2023-09-13)
Primary citation	Brandao, T.A.,Johnson, S.J.,Hengge, A.C. The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch.Biochem.Biophys., 525:53-59, 2012 Cited by PubMed: 22698963 DOI: 10.1016/j.abb.2012.06.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation