3QKQ
Protein Tyrosine Phosphatase 1B - W179F mutant bound with vanadate
Summary for 3QKQ
Entry DOI | 10.2210/pdb3qkq/pdb |
Related | 2CM2 3F9B 3QKN 3QKO 3QKP |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total) |
Functional Keywords | hydrolase, p-loop, wpd-loop, vanadate, protein phosphatase, egfr receptor, phosphoprotein |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 37839.97 |
Authors | Brandao, T.A.S.,Johnson, S.J.,Hengge, A.C. (deposition date: 2011-02-01, release date: 2012-08-08, Last modification date: 2023-09-13) |
Primary citation | Brandao, T.A.,Johnson, S.J.,Hengge, A.C. The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch.Biochem.Biophys., 525:53-59, 2012 Cited by PubMed: 22698963DOI: 10.1016/j.abb.2012.06.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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