8J6K
| Crystal structure of pro-interleukin-18 and caspase-4 complex | 分子名称: | Arginine ADP-riboxanase OspC3, Caspase-4 subunit p10, Caspase-4 subunit p20, ... | 著者 | Sun, Q, Hou, Y.J, Ding, J. | 登録日 | 2023-04-26 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | 主引用文献 | Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome. Nature, 624, 2023
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1J0S
| Solution structure of the human interleukin-18 | 分子名称: | Interleukin-18 | 著者 | Kato, Z, Jee, J, Shikano, H, Mishima, M, Ohki, I, Yoneda, T, Hara, T, Torigoe, K, Kondo, N, Shirakawa, M. | 登録日 | 2002-11-21 | 公開日 | 2003-11-11 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | The structure and binding mode of interleukin-18 Nat.Struct.Biol., 10, 2003
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4R6U
| IL-18 receptor complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-18, Interleukin-18 receptor 1 | 著者 | Wei, H, Wang, X. | 登録日 | 2014-08-26 | 公開日 | 2014-10-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for the specific recognition of IL-18 by its alpha receptor. Febs Lett., 588, 2014
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3F62
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8URV
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2VXT
| Crystal structure of human IL-18 complexed to murine reference antibody 125-2H Fab | 分子名称: | CHLORIDE ION, INTERLEUKIN-18, MAGNESIUM ION, ... | 著者 | Argiriadi, M.A, Xiang, T, Wu, C, Ghayur, T, Borhani, D.W. | 登録日 | 2008-07-10 | 公開日 | 2009-06-23 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Unusual Water-Mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18. J.Biol.Chem., 284, 2009
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8SPB
| Caspase-4/Pro-IL-18 complex | 分子名称: | Caspase-4 subunit p10, Caspase-4 subunit p20, Interleukin-18 | 著者 | Pascal, D, Dong, Y, Wu, H, Jon, K. | 登録日 | 2023-05-02 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into cytokine cleavage by inflammatory caspase-4. Nature, 624, 2023
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8SV1
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4EKX
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4XFU
| Structure of IL-18 SER Mutant V | 分子名称: | Interleukin-18 | 著者 | Krumm, B.E, Meng, X, Xiang, Y, Deng, J. | 登録日 | 2014-12-29 | 公開日 | 2015-06-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
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4XFT
| Structure of IL-18 SER Mutant III | 分子名称: | DIMETHYL SULFOXIDE, Interleukin-18 | 著者 | Krumm, B.E, Meng, X, Xiang, Y, Deng, J. | 登録日 | 2014-12-29 | 公開日 | 2015-06-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
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4XFS
| Structure of IL-18 SER Mutant I | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, Interleukin-18 | 著者 | Krumm, B.E, Meng, X, Xiang, Y, Deng, J. | 登録日 | 2014-12-28 | 公開日 | 2015-06-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
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4HJJ
| Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule | 分子名称: | Anti-IL12 Anti-IL18 DFab Heavy Chain, Anti-IL12 Anti-IL18 DFab Light Chain, CHLORIDE ION, ... | 著者 | Jakob, C.G, Edalji, R, Judge, R.A, DiGiammarino, E, Li, Y, Gu, J, Ghayur, T. | 登録日 | 2012-10-12 | 公開日 | 2013-05-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig[TM]) molecule MAbs, 5, 2013
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4EEE
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3WO2
| Crystal structure of human interleukin-18 | 分子名称: | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Interleukin-18, SULFATE ION | 著者 | Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H. | 登録日 | 2013-12-19 | 公開日 | 2014-12-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | The structural basis for receptor recognition of human interleukin-18 Nat Commun, 5, 2014
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3WO4
| Crystal structure of the IL-18 signaling ternary complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H. | 登録日 | 2013-12-19 | 公開日 | 2014-12-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | The structural basis for receptor recognition of human interleukin-18 Nat Commun, 5, 2014
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3WO3
| Crystal structure of IL-18 in complex with IL-18 receptor alpha | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H. | 登録日 | 2013-12-19 | 公開日 | 2014-12-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | The structural basis for receptor recognition of human interleukin-18 Nat Commun, 5, 2014
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7AL7
| The Crystal Structure of Human IL-18 in Complex With Human IL-18 Binding Protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutathione S-transferase class-mu 26 kDa isozyme,Interleukin-18, Interleukin-18-binding protein | 著者 | Detry, S, Andries, J, Bloch, Y, Clancy, D, Savvides, S.N. | 登録日 | 2020-10-05 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity. J.Biol.Chem., 298, 2022
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