3WO2

Crystal structure of human interleukin-18

Summary for 3WO2

• Entry DOI: 10.2210/pdb3wo2/pdb
• Related: 3WO3 3WO4
• Descriptor: Interleukin-18, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, SULFATE ION, ... (4 entities in total)
• Functional Keywords: beta trefoil fold, il-1 superfamily, immunity, inflammation, autoimmunity, allergy, interleukin-18 receptor alpha, interleukin-18 receptor beta, serum, immune system
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: Q14116
• Total number of polymer chains: 4
• Total formula weight: 80721.68

Authors

Tsutsumi, N.,Kimura, T.,Arita, K.,Ariyoshi, M.,Ohnishi, H.,Kondo, N.,Shirakawa, M.,Kato, Z.,Tochio, H. (deposition date: 2013-12-19, release date: 2014-12-17, Last modification date: 2023-11-08)

• Primary citation: Tsutsumi, N.,Kimura, T.,Arita, K.,Ariyoshi, M.,Ohnishi, H.,Yamamoto, T.,Zuo, X.,Maenaka, K.,Park, E.Y.,Kondo, N.,Shirakawa, M.,Tochio, H.,Kato, Z.; The structural basis for receptor recognition of human interleukin-18; Nat Commun, 5:5340-5340, 2014; PubMed: 25500532; DOI: 10.1038/ncomms6340

Experimental method

X-RAY DIFFRACTION (2.33 Å)