3WO2
Crystal structure of human interleukin-18
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006954 | biological_process | inflammatory response |
| A | 0006955 | biological_process | immune response |
| B | 0005125 | molecular_function | cytokine activity |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006954 | biological_process | inflammatory response |
| B | 0006955 | biological_process | immune response |
| C | 0005125 | molecular_function | cytokine activity |
| C | 0005615 | cellular_component | extracellular space |
| C | 0006954 | biological_process | inflammatory response |
| C | 0006955 | biological_process | immune response |
| D | 0005125 | molecular_function | cytokine activity |
| D | 0005615 | cellular_component | extracellular space |
| D | 0006954 | biological_process | inflammatory response |
| D | 0006955 | biological_process | immune response |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CPS A 201 |
| Chain | Residue |
| A | PRO43 |
| A | ILE48 |
| A | LYS67 |
| A | ILE71 |
| A | HOH318 |
| A | HOH375 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CPS A 202 |
| Chain | Residue |
| A | GLU156 |
| A | ASP35 |
| A | GLN154 |
| A | ASN155 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CPS A 203 |
| Chain | Residue |
| A | LYS4 |
| A | SER7 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 204 |
| Chain | Residue |
| A | ARG104 |
| A | SER105 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A 205 |
| Chain | Residue |
| A | ARG147 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CPS B 201 |
| Chain | Residue |
| B | ASP35 |
| B | GLN154 |
| B | ASN155 |
| B | GLU156 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CPS B 202 |
| Chain | Residue |
| B | PRO43 |
| B | LYS67 |
| B | CPS203 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CPS B 203 |
| Chain | Residue |
| B | LYS4 |
| B | SER7 |
| B | LEU9 |
| B | ASN87 |
| B | CPS202 |
| B | HOH390 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 204 |
| Chain | Residue |
| B | ARG147 |
| B | HOH384 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CPS C 201 |
| Chain | Residue |
| C | LEU9 |
| C | ASP35 |
| C | GLN154 |
| C | ASN155 |
| C | GLU156 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CPS C 202 |
| Chain | Residue |
| C | LEU9 |
| C | ILE71 |
| C | ASN87 |
| C | PRO88 |
| C | ASP90 |
| C | ASN91 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CPS C 203 |
| Chain | Residue |
| C | PRO43 |
| C | LYS67 |
| C | ILE71 |
| C | HOH315 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 204 |
| Chain | Residue |
| C | HIS109 |
| C | ASP110 |
| C | ASN111 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CPS D 201 |
| Chain | Residue |
| D | ARG39 |
| D | ASP40 |
| D | ALA42 |
| D | PRO43 |
| D | ILE48 |
| D | LYS67 |
| D | ILE71 |
| D | HOH314 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CPS D 202 |
| Chain | Residue |
| D | SER10 |
| D | VAL11 |
| D | GLN154 |
| D | GLU156 |
| D | ASP157 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CPS D 203 |
| Chain | Residue |
| D | LEU9 |
| D | ASN87 |
| D | PRO89 |
| D | ASP90 |
| D | ASN91 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Site: {"description":"Cleavage; by CASP3","evidences":[{"source":"PubMed","id":"37993714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9334240","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
