4ZFT
 
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3C0R
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6DGF
 | | Ubiquitin Variant bound to USP2 | | 分子名称: | Polyubiquitin-B, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 2, ... | | 著者 | Manczyk, N, Sicheri, F. | | 登録日 | 2018-05-17 | | 公開日 | 2019-02-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases.
J. Mol. Biol., 431, 2019
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5OHK
 | | Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (high resolution) | | 分子名称: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30, ZINC ION, ... | | 著者 | Gersch, M, Komander, D. | | 登録日 | 2017-07-17 | | 公開日 | 2017-09-20 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
Nat. Struct. Mol. Biol., 24, 2017
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6ASR
 | | REV1 UBM2 domain complex with ubiquitin | | 分子名称: | DNA repair protein REV1, NICKEL (II) ION, Ubiquitin | | 著者 | Miller, D.J. | | 登録日 | 2017-08-25 | | 公開日 | 2018-06-20 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.356 Å) | | 主引用文献 | Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction.
J. Mol. Biol., 430, 2018
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5XDP
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5ULK
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7MYH
 | | Ubiquitin variant UbV.k.2 in complex with Ube2k | | 分子名称: | GLYCEROL, Ubiquitin variant UbV.k.2, Ubiquitin-conjugating enzyme E2 K | | 著者 | Middleton, A.J, Day, C.L, Teyra, J, Sidhu, S.S. | | 登録日 | 2021-05-21 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.394 Å) | | 主引用文献 | Identification of Ubiquitin Variants That Inhibit the E2 Ubiquitin Conjugating Enzyme, Ube2k.
Acs Chem.Biol., 16, 2021
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7OJX
 | | E2 UBE2K covalently linked to donor Ub, acceptor di-Ub, and RING E3 primed for K48-linked Ub chain synthesis | | 分子名称: | 1,1'-ethane-1,2-diylbis(1H-pyrrole-2,5-dione), E3 ubiquitin-protein ligase RNF38, Polyubiquitin-B, ... | | 著者 | Majorek, K.A, Nakasone, M.A, Huang, D.T. | | 登録日 | 2021-05-17 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension.
Nat.Chem.Biol., 18, 2022
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3IFW
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5EYA
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1TBE
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7BU0
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8OYP
 | | Crystal structure of Ubiquitin specific protease 11 (USP11) in complex with a substrate mimetic | | 分子名称: | CADMIUM ION, CHLORIDE ION, GLYCEROL, ... | | 著者 | Maurer, S.K, Caulton, S.G, Ward, S.J, Emsley, J, Dreveny, I. | | 登録日 | 2023-05-05 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Ubiquitin-specific protease 11 structure in complex with an engineered substrate mimetic reveals a molecular feature for deubiquitination selectivity.
J.Biol.Chem., 299, 2023
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6IF1
 | | Crystal structure of Ube2K and K48-linked di-ubiquitin complex | | 分子名称: | Ubiquitin, Ubiquitin-conjugating enzyme E2 K | | 著者 | Lee, J.-G, Youn, H.-S, Lee, Y, An, J.Y, Park, K.R, Kang, J.Y, Lim, J.J, Eom, S.H. | | 登録日 | 2018-09-18 | | 公開日 | 2018-11-21 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.466 Å) | | 主引用文献 | Crystal structure of the Ube2K/E2-25K and K48-linked di-ubiquitin complex provides structural insight into the mechanism of K48-specific ubiquitin chain synthesis.
Biochem. Biophys. Res. Commun., 506, 2018
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7M2K
 | | CDC34A-Ubiquitin-2ab inhibitor complex | | 分子名称: | 4-[(3',5'-dichloro[1,1'-biphenyl]-4-yl)methyl]-N-ethyl-1-(methoxyacetyl)piperidine-4-carboxamide, Ubiquitin, Ubiquitin-conjugating enzyme E2 R1 | | 著者 | Ceccarelli, D.F, St-Cyr, D, Tyers, M, Sicheri, F. | | 登録日 | 2021-03-16 | | 公開日 | 2021-11-03 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.
Sci Adv, 7, 2021
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6LP2
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7US1
 | | Structure of parkin (R0RB) bound to two phospho-ubiquitin molecules | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase parkin, ... | | 著者 | Fakih, R, Sauve, V, Gehring, K. | | 登録日 | 2022-04-22 | | 公開日 | 2022-06-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.484 Å) | | 主引用文献 | Structure of the second phosphoubiquitin-binding site in parkin.
J.Biol.Chem., 298, 2022
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5BNB
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3OJ3
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5OHL
 | | K6-specific affimer bound to K6 diUb | | 分子名称: | GLYCEROL, K6-specific affimer, POLYETHYLENE GLYCOL (N=34), ... | | 著者 | Michel, M.A, Komander, D. | | 登録日 | 2017-07-17 | | 公開日 | 2017-10-04 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling.
Mol. Cell, 68, 2017
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6FX4
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6OAM
 | | Crystal Structure of ChlaDUB2 DUB domain | | 分子名称: | Deubiquitinase and deneddylase Dub2, Ubiquitin | | 著者 | Hausman, J.M, Das, C. | | 登録日 | 2019-03-17 | | 公開日 | 2020-04-22 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.503 Å) | | 主引用文献 | The Two Deubiquitinating Enzymes fromChlamydia trachomatisHave Distinct Ubiquitin Recognition Properties.
Biochemistry, 59, 2020
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5IBK
 | | Skp1-F-box in complex with a ubiquitin variant | | 分子名称: | F-box/WD repeat-containing protein 7, Polyubiquitin-B, S-phase kinase-associated protein 1,S-phase kinase-associated protein 1 | | 著者 | Orlicky, S, Sicheri, F. | | 登録日 | 2016-02-22 | | 公開日 | 2016-03-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.503 Å) | | 主引用文献 | Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.
Proc.Natl.Acad.Sci.USA, 113, 2016
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7XCR
 | | Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 1:1 complex | | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B type 1-K, ... | | 著者 | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | | 登録日 | 2022-03-25 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-09-07 | | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | | 主引用文献 | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity.
Nat.Chem.Biol., 18, 2022
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