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PDB: 27 件
5L0R
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BU of 5l0r by Molmil
human POGLUT1 in complex with Notch1 EGF12 and UDP
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者Li, Z, Rini, J.M.
登録日2016-07-28
公開日2017-08-09
最終更新日2021-03-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis of Notch O-glucosylation and O-xylosylation by mammalian protein-O-glucosyltransferase 1 (POGLUT1).
Nat Commun, 8, 2017
2F8Y
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BU of 2f8y by Molmil
Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution.
分子名称: Notch homolog 1, translocation-associated (Drosophila), SULFATE ION
著者Nam, Y, Sliz, P, Blacklow, S.C.
登録日2005-12-04
公開日2006-04-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Cell(Cambridge,Mass.), 124, 2006
4D0E
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BU of 4d0e by Molmil
Human Notch1 EGF domains 11-13 mutant GlcNAc-fucose disaccharide modified at T466
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose, CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
著者Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A.
登録日2014-04-25
公開日2014-05-21
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
4CUD
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BU of 4cud by Molmil
Human Notch1 EGF domains 11-13 mutant fucosylated at T466
分子名称: CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, alpha-L-fucopyranose
著者Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A.
登録日2014-03-18
公開日2014-05-21
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
2HE0
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BU of 2he0 by Molmil
Crystal structure of a human Notch1 ankyrin domain mutant
分子名称: 1,2-ETHANEDIOL, Notch1 preproprotein variant
著者Gupta, D, Ehebauer, M.T, Chirgadze, D.Y, Martinez Arias, A, Blundell, T.L.
登録日2006-06-21
公開日2006-07-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of a human Notch1 ankyrin domain mutant
TO BE PUBLISHED
1YYH
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BU of 1yyh by Molmil
Crystal structure of the human Notch 1 ankyrin domain
分子名称: Notch 1, ankyrin domain
著者Ehebauer, M.T, Chirgadze, D.Y, Hayward, P, Martinez-Arias, A, Blundell, T.L.
登録日2005-02-25
公開日2005-08-16
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.901 Å)
主引用文献High-resolution crystal structure of the human Notch 1 ankyrin domain
Biochem.J., 392, 2005
3ETO
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BU of 3eto by Molmil
2 Angstrom Xray structure of the NOTCH1 Negative Regulatory Region (NRR)
分子名称: CALCIUM ION, CHLORIDE ION, GLYCEROL, ...
著者Gordon, W.R, Blacklow, S.C.
登録日2008-10-08
公開日2008-12-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.
Blood, 113, 2009
5UB5
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BU of 5ub5 by Molmil
human POGLUT1 in complex with human Notch1 EGF12 S458T mutant and UDP
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurogenic locus notch homolog protein 1, ...
著者Li, Z, Rini, J.M.
登録日2016-12-20
公開日2017-08-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.089 Å)
主引用文献Structural basis of Notch O-glucosylation and O-xylosylation by mammalian protein-O-glucosyltransferase 1 (POGLUT1).
Nat Commun, 8, 2017
3L95
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BU of 3l95 by Molmil
Crystal structure of the human Notch1 Negative Regulatory Region (NRR) bound to the fab fragment of an antagonist antibody
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurogenic locus notch homolog protein 1, ...
著者Hymowitz, S.G, de Leon, G.P.
登録日2010-01-04
公開日2010-03-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Therapeutic antibody targeting of individual Notch receptors.
Nature, 464, 2010
4CUF
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BU of 4cuf by Molmil
Human Notch1 EGF domains 11-13 mutant T466S
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
著者Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A.
登録日2014-03-18
公開日2014-05-14
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
5FMA
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BU of 5fma by Molmil
human Notch 1, EGF 4-7
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ...
著者Weisshuhn, P.C, Sheppard, D, Taylor, P, Whiteman, P, Lea, S.M, Handford, P.A, Redfield, C.
登録日2015-11-02
公開日2016-04-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies.
Structure, 24, 2016
2VJ3
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BU of 2vj3 by Molmil
Human Notch-1 EGFs 11-13
分子名称: CALCIUM ION, CHLORIDE ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, ...
著者Johnson, S, Cordle, J, Tay, J.Z, Roversi, P, Lea, S.M.
登録日2007-12-06
公開日2008-07-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A Conserved Face of the Jagged/Serrate Dsl Domain is Involved in Notch Trans-Activation and Cis-Inhibition.
Nat.Struct.Mol.Biol., 15, 2008
6IDF
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BU of 6idf by Molmil
Cryo-EM structure of gamma secretase in complex with a Notch fragment
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yang, G, Zhou, R, Zhou, Q, Guo, X, Yan, C, Ke, M, Lei, J, Shi, Y.
登録日2018-09-09
公開日2018-12-26
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural basis of Notch recognition by human gamma-secretase
Nature, 565, 2019
4D0F
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BU of 4d0f by Molmil
Human Notch1 EGF domains 11-13 mutant T466A
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
著者Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A.
登録日2014-04-25
公開日2014-05-21
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
5FM9
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BU of 5fm9 by Molmil
human Notch 1, EGF 4-7
分子名称: CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
著者Weisshuhn, P.C, Sheppard, D, Taylor, P, Whiteman, P, Lea, S.M, Handford, P.A, Redfield, C.
登録日2015-11-02
公開日2016-04-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies.
Structure, 24, 2016
4CUE
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BU of 4cue by Molmil
Human Notch1 EGF domains 11-13 mutant T466V
分子名称: CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
著者Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A.
登録日2014-03-18
公開日2014-05-21
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
3I08
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BU of 3i08 by Molmil
Crystal structure of the S1-cleaved Notch1 Negative Regulatory Region (NRR)
分子名称: CALCIUM ION, CHLORIDE ION, Neurogenic locus notch homolog protein 1
著者Gordon, W.R, Blacklow, S.C.
登録日2009-06-24
公開日2009-09-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.
Plos One, 4, 2009
2F8X
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BU of 2f8x by Molmil
Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence
分子名称: 5'-D(*GP*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*AP*AP*A)-3', 5'-D(*TP*TP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*TP*AP*AP*C)-3', Mastermind-like protein 1, ...
著者Nam, Y, Sliz, P, Blacklow, S.C.
登録日2005-12-04
公開日2006-04-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Cell(Cambridge,Mass.), 124, 2006
3NBN
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BU of 3nbn by Molmil
Crystal structure of a dimer of Notch Transcription Complex trimers on HES1 DNA
分子名称: DNA, HES1 promoter, Mastermind-like protein 1, ...
著者Arnett, K.L, Blacklow, S.C.
登録日2010-06-03
公開日2010-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.
Nat.Struct.Mol.Biol., 17, 2010
6PY8
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BU of 6py8 by Molmil
Crystal structure of the RBPJ-NOTCH1-NRARP ternary complex bound to DNA
分子名称: DNA, Neurogenic locus notch homolog protein 1, Notch-regulated ankyrin repeat-containing protein, ...
著者Jarrett, S.M, Seegar, T.C.M, Blacklow, S.C.
登録日2019-07-29
公開日2019-08-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.75 Å)
主引用文献Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling.
Sci.Signal., 12, 2019
3V79
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BU of 3v79 by Molmil
Structure of human Notch1 transcription complex including CSL, RAM, ANK, and MAML-1 on HES-1 promoter DNA sequence
分子名称: DNA 5'-D(*GP*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*AP*AP*A)-3', DNA 5'-D(*TP*TP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*TP*AP*AP*C)-3', Mastermind-like protein 1, ...
著者Nam, Y, Sliz, P, Blacklow, S.
登録日2011-12-20
公開日2012-02-15
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.85 Å)
主引用文献Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes.
Structure, 20, 2012
1PB5
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BU of 1pb5 by Molmil
NMR Structure of a Prototype LNR Module from Human Notch1
分子名称: CALCIUM ION, Neurogenic locus notch homolog protein 1
著者Vardar, D, North, C.L, Sanchez-Irizarry, C, Aster, J.C, Blacklow, S.C.
登録日2003-05-14
公開日2003-06-17
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Nuclear Magnetic Resonance Structure of a Prototype Lin12-Notch Repeat Module from Human Notch1
Biochemistry, 42, 2003
8ORZ
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BU of 8orz by Molmil
Solution NMR structure of Notch1 G1740-1743 TMD
分子名称: Notch 1 extracellular truncation
著者Guschtschin-Schmidt, N, Muhle-Goll, C.
登録日2023-04-17
公開日2023-08-16
最終更新日2023-08-23
実験手法SOLUTION NMR
主引用文献Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by gamma-Secretase.
J.Mol.Biol., 435, 2023
8ORY
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BU of 8ory by Molmil
Solution NMR structure of Notch1 L1740-1743 TMD
分子名称: Notch 1 extracellular truncation
著者Guschtschin-Schmidt, N, Muhle-Goll, C.
登録日2023-04-17
公開日2023-08-16
最終更新日2023-08-23
実験手法SOLUTION NMR
主引用文献Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by gamma-Secretase.
J.Mol.Biol., 435, 2023
8OR5
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BU of 8or5 by Molmil
Solution NMR structure of Notch1 TMD
分子名称: Notch 1 extracellular truncation
著者Guschtschin-Schmidt, N, Muhle-Goll, C.
登録日2023-04-13
公開日2023-08-16
最終更新日2023-08-23
実験手法SOLUTION NMR
主引用文献Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by gamma-Secretase.
J.Mol.Biol., 435, 2023

 

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