3V79
Structure of human Notch1 transcription complex including CSL, RAM, ANK, and MAML-1 on HES-1 promoter DNA sequence
Summary for 3V79
Entry DOI | 10.2210/pdb3v79/pdb |
Descriptor | Neurogenic locus notch homolog protein 1, Recombining binding protein suppressor of hairless, Mastermind-like protein 1, ... (6 entities in total) |
Functional Keywords | beta-trefoil, ankyrin, transcription activation, dna binding, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein (By similarity). Notch 1 intracellular domain: Nucleus (By similarity): P46531 Nucleus: Q06330 Nucleus speckle: Q92585 |
Total number of polymer chains | 6 |
Total formula weight | 98133.92 |
Authors | Nam, Y.,Sliz, P.,Blacklow, S. (deposition date: 2011-12-20, release date: 2012-02-15, Last modification date: 2023-09-13) |
Primary citation | Choi, S.H.,Wales, T.E.,Nam, Y.,O'Donovan, D.J.,Sliz, P.,Engen, J.R.,Blacklow, S.C. Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes. Structure, 20:340-349, 2012 Cited by PubMed: 22325781DOI: 10.1016/j.str.2011.12.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.85 Å) |
Structure validation
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