3V79

Structure of human Notch1 transcription complex including CSL, RAM, ANK, and MAML-1 on HES-1 promoter DNA sequence

Summary for 3V79

Entry DOI	10.2210/pdb3v79/pdb
Descriptor	Neurogenic locus notch homolog protein 1, Recombining binding protein suppressor of hairless, Mastermind-like protein 1, ... (6 entities in total)
Functional Keywords	beta-trefoil, ankyrin, transcription activation, dna binding, transcription-dna complex, transcription/dna
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Single-pass type I membrane protein (By similarity). Notch 1 intracellular domain: Nucleus (By similarity): P46531 Nucleus: Q06330 Nucleus speckle: Q92585
Total number of polymer chains	6
Total formula weight	98133.92
Authors	Nam, Y.,Sliz, P.,Blacklow, S. (deposition date: 2011-12-20, release date: 2012-02-15, Last modification date: 2023-09-13)
Primary citation	Choi, S.H.,Wales, T.E.,Nam, Y.,O'Donovan, D.J.,Sliz, P.,Engen, J.R.,Blacklow, S.C. Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes. Structure, 20:340-349, 2012 Cited by PubMed: 22325781 DOI: 10.1016/j.str.2011.12.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.85 Å)

Structure validation