3V79

Structure of human Notch1 transcription complex including CSL, RAM, ANK, and MAML-1 on HES-1 promoter DNA sequence

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (K)	Neurogenic locus notch homolog protein 1	polymer	256	27885.0	1	UniProt (P46531) Pfam (PF00023) Pfam (PF12796)	Homo sapiens (human)	Notch 1, hN1, Translocation-associated notch protein TAN-1, Notch 1 extracellular truncation, Notch 1 intracellular domain, NICD
2	B (C)	Recombining binding protein suppressor of hairless	polymer	434	49294.2	1	UniProt (Q06330) Pfam (PF09271) Pfam (PF09270) Pfam (PF20144)	Homo sapiens (human)	CBF-1, J kappa-recombination signal-binding protein, RBP-J kappa, RBP-J, RBP-JK, Renal carcinoma antigen NY-REN-30
3	C (M)	Mastermind-like protein 1	polymer	63	7532.8	1	UniProt (Q92585) Pfam (PF09596)	Homo sapiens (human)	Mam-1
4	D (X)	DNA 5'-D(*GP*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*AP*AP*A)-3'	polymer	18	5628.7	1
5	E (Y)	DNA 5'-D(*TP*TP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*TP*AP*AP*C)-3'	polymer	18	5401.5	1
6	F (R)	RAM	polymer	19	2391.7	1	UniProt (by SIFTS) (P46531)	Homo sapiens

Sequence modifications

K: 1873 - 2127 (UniProt: P46531)

PDB	External Database	Details
Gly 1872	-	expression tag

C: 9 - 435 (UniProt: Q06330)

PDB	External Database	Details
Met 8	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
His 438	-	expression tag
His 439	-	expression tag
His 440	-	expression tag
His 441	-	expression tag

M: 13 - 74 (UniProt: Q92585)

PDB	External Database	Details
Gly 12	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	98133.9
All*	Total formula weight	98133.9

*Water molecules are not included.