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PDB: 38 件

7A5V
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CryoEM structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer, in complex with histamine and megabody Mb25 in lipid nanodisc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
著者Nakane, T, Kotecha, A, Sente, A, Yamashita, K, McMullan, G, Masiulis, S, Brown, P.M.G.E, Grigoras, I.T, Malinauskaite, L, Malinauskas, T, Miehling, J, Yu, L, Karia, D, Pechnikova, E.V, de Jong, E, Keizer, J, Bischoff, M, McCormack, J, Tiemeijer, P, Hardwick, S.W, Chirgadze, D.Y, Murshudov, G, Aricescu, A.R, Scheres, S.H.W.
登録日2020-08-22
公開日2020-11-18
最終更新日2020-11-25
実験手法ELECTRON MICROSCOPY (1.7 Å)
主引用文献Single-particle cryo-EM at atomic resolution.
Nature, 587, 2020
8BHG
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GABA-A receptor a5 heteromer - a5V2 - Bretazenil
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Bretazenil, DECYL-BETA-D-MALTOPYRANOSIDE, ...
著者Miller, P.S, Malinauskas, T.M, Omari, K.E, Aricescu, A.R.
登録日2022-10-31
公開日2023-11-15
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
6QFA
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CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody Mb25
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit beta-3, HISTAMINE, ...
著者Uchanski, T, Masiulis, S, Fischer, B, Kalichuk, V, Wohlkoening, A, Zoegg, T, Remaut, H, Vranken, W, Aricescu, A.R, Pardon, E, Steyaert, J.
登録日2019-01-09
公開日2021-08-04
実験手法ELECTRON MICROSCOPY (2.49 Å)
主引用文献Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
Nat.Methods, 18, 2021
7QN5
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Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with nanobody Nb25
分子名称: 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R.
登録日2021-12-20
公開日2022-04-13
最終更新日2022-05-04
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Differential assembly diversifies GABA A receptor structures and signalling.
Nature, 604, 2022
8BHB
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GABA-A receptor a5 homomer - a5V3 - RO154513
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5, ethyl 8-[(azanylidene-$l^{4}-azanylidene)amino]-5-methyl-6-oxidanylidene-4~{H}-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
著者Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Chirgadze, D.Y, Wahid, A.A.
登録日2022-10-30
公開日2023-11-01
最終更新日2023-12-27
実験手法ELECTRON MICROSCOPY (2.54 Å)
主引用文献The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
8BGI
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GABA-A receptor a5 homomer - a5V1 - Flumazenil
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5, Pregnanolone, ...
著者Miller, P.S, Malinauskas, T.M, Omari, K.E, Aricescu, A.R.
登録日2022-10-27
公開日2023-11-08
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
8BHI
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GABA-A receptor a5 homomer - a5V3 - RO5211223
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5, [1,1-bis(oxidanylidene)-1,4-thiazinan-4-yl]-[6-[[5-methyl-3-(6-methylpyridin-3-yl)-1,2-oxazol-4-yl]methoxy]pyridin-3-yl]methanone
著者Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Chirgadze, D.Y.
登録日2022-10-31
公開日2023-11-01
最終更新日2023-12-27
実験手法ELECTRON MICROSCOPY (2.67 Å)
主引用文献The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
8BHA
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GABA-A receptor a5 homomer - a5V3 - Basmisanil - HR
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Basmisanil, Gamma-aminobutyric acid receptor subunit alpha-5
著者Malinauskas, T.M, Wahid, A.A, Hardwick, S.W, Chirgadze, D.Y, Miller, P.S.
登録日2022-10-30
公開日2023-11-01
最終更新日2023-12-27
実験手法ELECTRON MICROSCOPY (2.67 Å)
主引用文献The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
7QNE
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Cryo-EM structure of human full-length synaptic alpha1beta3gamma2 GABA(A)R in complex with Ro15-4513 and megabody Mb38
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
著者Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R.
登録日2021-12-20
公開日2022-04-13
最終更新日2022-05-04
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Differential assembly diversifies GABA A receptor structures and signalling.
Nature, 604, 2022
7PBZ
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a1b3 GABA-A receptor + GABA + Zn2+
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DECANE, ...
著者Miller, P.S, Kasaragod, V.B.
登録日2021-08-03
公開日2022-02-09
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (2.79 Å)
主引用文献Mechanisms of inhibition and activation of extrasynaptic alpha beta GABA A receptors.
Nature, 602, 2022
7QNC
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Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with THIP (gaboxadol), histamine and nanobody Nb25
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one, ...
著者Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R.
登録日2021-12-20
公開日2022-04-13
最終更新日2022-04-20
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Differential assembly diversifies GABA A receptor structures and signalling.
Nature, 604, 2022
7QN6
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Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with nanobody Nb25
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R.
登録日2021-12-20
公開日2022-04-13
最終更新日2022-04-20
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Differential assembly diversifies GABA A receptor structures and signalling.
Nature, 604, 2022
7QN9
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Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with GABA, histamine and nanobody Nb25 in a pre-open/closed state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DECANE, ...
著者Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R.
登録日2021-12-20
公開日2022-04-13
最終更新日2022-04-20
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Differential assembly diversifies GABA A receptor structures and signalling.
Nature, 604, 2022
8BHO
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GABA-A receptor a5 homomer - a5V3 - L655708
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5, ethyl (7~{S})-15-methoxy-12-oxidanylidene-2,4,11-triazatetracyclo[11.4.0.0^{2,6}.0^{7,11}]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate
著者Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Chirgadze, D.Y.
登録日2022-10-31
公開日2023-11-01
最終更新日2023-12-27
実験手法ELECTRON MICROSCOPY (2.93 Å)
主引用文献The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
8BHM
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GABA-A receptor a5 homomer - a5V3 - DMCM
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5, methyl 4-ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylate
著者Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Chirgadze, D.Y.
登録日2022-10-31
公開日2023-11-01
最終更新日2023-12-27
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
4COF
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Crystal structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, CHLORIDE ION, ...
著者Miller, P.S, Aricescu, A.R.
登録日2014-01-28
公開日2014-06-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献Crystal Structure of a Human Gabaa Receptor
Nature, 512, 2014
7QN7
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Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with GABA, histamine and nanobody Nb25
分子名称: 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R.
登録日2021-12-20
公開日2022-04-13
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Differential assembly diversifies GABA A receptor structures and signalling.
Nature, 604, 2022
7QNA
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Cryo-EM structure of human full-length alpha4beta3gamma2 GABA(A)R in complex with GABA and nanobody Nb25
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ...
著者Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R.
登録日2021-12-20
公開日2022-04-13
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Differential assembly diversifies GABA A receptor structures and signalling.
Nature, 604, 2022
7PC0
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GABA-A receptor bound by a-Cobratoxin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-cobratoxin, ...
著者Kasaragod, V.B, Miller, P.S.
登録日2021-08-03
公開日2022-02-09
最終更新日2022-03-02
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Mechanisms of inhibition and activation of extrasynaptic alpha beta GABA A receptors.
Nature, 602, 2022
7PBD
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a1b3 GABA-A receptor + GABA
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ...
著者Miller, P.S, Kasaragod, V.B.
登録日2021-08-02
公開日2022-02-09
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (3.04 Å)
主引用文献Mechanisms of inhibition and activation of extrasynaptic alpha beta GABA A receptors.
Nature, 602, 2022
6HUJ
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CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with picrotoxin, GABA and megabody Mb38.
分子名称: (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ...
著者Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R.
登録日2018-10-08
公開日2019-01-02
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (3.04 Å)
主引用文献GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565, 2019
7QNB
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Cryo-EM structure of human full-length beta3gamma2 GABA(A)R in complex with GABA and nanobody Nb25
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ...
著者Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R.
登録日2021-12-20
公開日2022-04-13
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Differential assembly diversifies GABA A receptor structures and signalling.
Nature, 604, 2022
7QN8
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Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with histamine and nanobody Nb25
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit beta-3, ...
著者Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R.
登録日2021-12-20
公開日2022-04-13
最終更新日2022-04-20
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Differential assembly diversifies GABA A receptor structures and signalling.
Nature, 604, 2022
6HUG
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CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with picrotoxin and megabody Mb38.
分子名称: (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-1, ...
著者Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R.
登録日2018-10-08
公開日2019-01-02
最終更新日2022-03-30
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565, 2019
5O8F
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Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 and pregnanolone
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit alpha-5,Gamma-aminobutyric acid receptor subunit alpha-5, Nanobody Nb25, ...
著者Miller, P.S, Scott, S, Masiulis, S, De Colibus, L, Pardon, E, Steyaert, J, Aricescu, A.R.
登録日2017-06-13
公開日2017-11-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis for GABAA receptor potentiation by neurosteroids.
Nat. Struct. Mol. Biol., 24, 2017

 

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