5O8F
Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 and pregnanolone
Summary for 5O8F
Entry DOI | 10.2210/pdb5o8f/pdb |
Descriptor | Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit alpha-5,Gamma-aminobutyric acid receptor subunit alpha-5, Nanobody Nb25, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | gabaa receptor, pregnanolone, nanobody complex, neurosteroid, ion channel, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 10 |
Total formula weight | 285317.35 |
Authors | Miller, P.S.,Scott, S.,Masiulis, S.,De Colibus, L.,Pardon, E.,Steyaert, J.,Aricescu, A.R. (deposition date: 2017-06-13, release date: 2017-11-01, Last modification date: 2024-01-17) |
Primary citation | Miller, P.S.,Scott, S.,Masiulis, S.,De Colibus, L.,Pardon, E.,Steyaert, J.,Aricescu, A.R. Structural basis for GABAA receptor potentiation by neurosteroids. Nat. Struct. Mol. Biol., 24:986-992, 2017 Cited by PubMed: 28991263DOI: 10.1038/nsmb.3484 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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