6HUG

CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with picrotoxin and megabody Mb38.

Summary for 6HUG

Entry DOI	10.2210/pdb6hug/pdb
EMDB information	0275
Descriptor	Gamma-aminobutyric acid receptor subunit alpha-1, (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, Gamma-aminobutyric acid receptor subunit beta-3, ... (10 entities in total)
Functional Keywords	gabaar, ptx, membrane, channel, nanobody, megabody, cys-loop, plgic, inhibition, signalling, cns, neurons, chloride, ion, gaba, picrotoxin, membrane protein
Biological source	Bos taurus (Bovine) More
Total number of polymer chains	6
Total formula weight	330974.45
Authors	Masiulis, S.,Desai, R.,Uchanski, T.,Serna Martin, I.,Laverty, D.,Karia, D.,Malinauskas, T.,Jasenko, Z.,Pardon, E.,Kotecha, A.,Steyaert, J.,Miller, K.W.,Aricescu, A.R. (deposition date: 2018-10-08, release date: 2019-01-02, Last modification date: 2022-03-30)
Primary citation	Masiulis, S.,Desai, R.,Uchanski, T.,Serna Martin, I.,Laverty, D.,Karia, D.,Malinauskas, T.,Zivanov, J.,Pardon, E.,Kotecha, A.,Steyaert, J.,Miller, K.W.,Aricescu, A.R. GABAAreceptor signalling mechanisms revealed by structural pharmacology. Nature, 565:454-459, 2019 Cited by PubMed: 30602790 DOI: 10.1038/s41586-018-0832-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.1 Å)

Structure validation