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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6HUG

CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with picrotoxin and megabody Mb38.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0004890molecular_functionGABA-A receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005254molecular_functionchloride channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006821biological_processchloride transport
A0007214biological_processgamma-aminobutyric acid signaling pathway
A0008503molecular_functionbenzodiazepine receptor activity
A0016020cellular_componentmembrane
A0022851molecular_functionGABA-gated chloride ion channel activity
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0032590cellular_componentdendrite membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034707cellular_componentchloride channel complex
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0051932biological_processsynaptic transmission, GABAergic
A0098794cellular_componentpostsynapse
A0099634cellular_componentpostsynaptic specialization membrane
A1902476biological_processchloride transmembrane transport
A1902711cellular_componentGABA-A receptor complex
A1904862biological_processinhibitory synapse assembly
B0004888molecular_functiontransmembrane signaling receptor activity
B0004890molecular_functionGABA-A receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005254molecular_functionchloride channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006821biological_processchloride transport
B0007165biological_processsignal transduction
B0007214biological_processgamma-aminobutyric acid signaling pathway
B0007268biological_processchemical synaptic transmission
B0007399biological_processnervous system development
B0007420biological_processbrain development
B0007612biological_processlearning
B0007613biological_processmemory
B0009410biological_processresponse to xenobiotic stimulus
B0009986cellular_componentcell surface
B0016020cellular_componentmembrane
B0019098biological_processreproductive behavior
B0021549biological_processcerebellum development
B0022851molecular_functionGABA-gated chloride ion channel activity
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0034220biological_processmonoatomic ion transmembrane transport
B0034707cellular_componentchloride channel complex
B0035176biological_processsocial behavior
B0035640biological_processexploration behavior
B0042747biological_processcircadian sleep/wake cycle, REM sleep
B0042802molecular_functionidentical protein binding
B0043197cellular_componentdendritic spine
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0048666biological_processneuron development
B0051932biological_processsynaptic transmission, GABAergic
B0060021biological_processroof of mouth development
B0060022biological_processhard palate development
B0060080biological_processinhibitory postsynaptic potential
B0060119biological_processinner ear receptor cell development
B0060384biological_processinnervation
B0061744biological_processmotor behavior
B0071294biological_processcellular response to zinc ion
B0071420biological_processcellular response to histamine
B0072347biological_processresponse to anesthetic
B0090102biological_processcochlea development
B0098982cellular_componentGABA-ergic synapse
B0099634cellular_componentpostsynaptic specialization membrane
B1902476biological_processchloride transmembrane transport
B1902711cellular_componentGABA-A receptor complex
B1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B1904862biological_processinhibitory synapse assembly
C0004888molecular_functiontransmembrane signaling receptor activity
C0004890molecular_functionGABA-A receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0006821biological_processchloride transport
C0007214biological_processgamma-aminobutyric acid signaling pathway
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
D0004888molecular_functiontransmembrane signaling receptor activity
D0004890molecular_functionGABA-A receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005254molecular_functionchloride channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006821biological_processchloride transport
D0007214biological_processgamma-aminobutyric acid signaling pathway
D0008503molecular_functionbenzodiazepine receptor activity
D0016020cellular_componentmembrane
D0022851molecular_functionGABA-gated chloride ion channel activity
D0030659cellular_componentcytoplasmic vesicle membrane
D0031410cellular_componentcytoplasmic vesicle
D0032590cellular_componentdendrite membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034707cellular_componentchloride channel complex
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0051932biological_processsynaptic transmission, GABAergic
D0098794cellular_componentpostsynapse
D0099634cellular_componentpostsynaptic specialization membrane
D1902476biological_processchloride transmembrane transport
D1902711cellular_componentGABA-A receptor complex
D1904862biological_processinhibitory synapse assembly
E0004888molecular_functiontransmembrane signaling receptor activity
E0004890molecular_functionGABA-A receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005254molecular_functionchloride channel activity
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006821biological_processchloride transport
E0007165biological_processsignal transduction
E0007214biological_processgamma-aminobutyric acid signaling pathway
E0007268biological_processchemical synaptic transmission
E0007399biological_processnervous system development
E0007420biological_processbrain development
E0007612biological_processlearning
E0007613biological_processmemory
E0009410biological_processresponse to xenobiotic stimulus
E0009986cellular_componentcell surface
E0016020cellular_componentmembrane
E0019098biological_processreproductive behavior
E0021549biological_processcerebellum development
E0022851molecular_functionGABA-gated chloride ion channel activity
E0030659cellular_componentcytoplasmic vesicle membrane
E0031410cellular_componentcytoplasmic vesicle
E0034220biological_processmonoatomic ion transmembrane transport
E0034707cellular_componentchloride channel complex
E0035176biological_processsocial behavior
E0035640biological_processexploration behavior
E0042747biological_processcircadian sleep/wake cycle, REM sleep
E0042802molecular_functionidentical protein binding
E0043197cellular_componentdendritic spine
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0048666biological_processneuron development
E0051932biological_processsynaptic transmission, GABAergic
E0060021biological_processroof of mouth development
E0060022biological_processhard palate development
E0060080biological_processinhibitory postsynaptic potential
E0060119biological_processinner ear receptor cell development
E0060384biological_processinnervation
E0061744biological_processmotor behavior
E0071294biological_processcellular response to zinc ion
E0071420biological_processcellular response to histamine
E0072347biological_processresponse to anesthetic
E0090102biological_processcochlea development
E0098982cellular_componentGABA-ergic synapse
E0099634cellular_componentpostsynaptic specialization membrane
E1902476biological_processchloride transmembrane transport
E1902711cellular_componentGABA-A receptor complex
E1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E1904862biological_processinhibitory synapse assembly
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CmMdLrrYPlDeqnC
ChainResidueDetails
BCYS136-CYS150
ACYS139-CYS153
CCYS151-CYS165
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues162
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"P14867","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues13
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues31
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P14867","evidenceCode":"ECO:0000250"},{"source":"UniProtKB","id":"P62813","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P62813","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues5
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues170
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues6
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues22
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues6
DetailsBinding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4COF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"30140029","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A96","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30140029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues83
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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