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6HUJ

CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with picrotoxin, GABA and megabody Mb38.

Summary for 6HUJ
Entry DOI10.2210/pdb6huj/pdb
EMDB information0279
DescriptorGamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, GAMMA-AMINO-BUTANOIC ACID, ... (11 entities in total)
Functional Keywordsgabaar, ptx, membrane, channel, nanobody, megabody, cys-loop, plgic, inhibition, signalling, cns, neurons, chloride, ion, gaba, picrotoxin, membrane protein
Biological sourceBos taurus (Bovine)
More
Total number of polymer chains6
Total formula weight336985.43
Authors
Masiulis, S.,Desai, R.,Uchanski, T.,Serna Martin, I.,Laverty, D.,Karia, D.,Malinauskas, T.,Jasenko, Z.,Pardon, E.,Kotecha, A.,Steyaert, J.,Miller, K.W.,Aricescu, A.R. (deposition date: 2018-10-08, release date: 2019-01-02, Last modification date: 2023-11-15)
Primary citationMasiulis, S.,Desai, R.,Uchanski, T.,Serna Martin, I.,Laverty, D.,Karia, D.,Malinauskas, T.,Zivanov, J.,Pardon, E.,Kotecha, A.,Steyaert, J.,Miller, K.W.,Aricescu, A.R.
GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565:454-459, 2019
Cited by
PubMed: 30602790
DOI: 10.1038/s41586-018-0832-5
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.04 Å)
Structure validation

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