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6HUJ

CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with picrotoxin, GABA and megabody Mb38.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0004890molecular_functionGABA-A receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005254molecular_functionchloride channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006821biological_processchloride transport
A0007214biological_processgamma-aminobutyric acid signaling pathway
A0008503molecular_functionbenzodiazepine receptor activity
A0016020cellular_componentmembrane
A0016917molecular_functionGABA receptor activity
A0022851molecular_functionGABA-gated chloride ion channel activity
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0032590cellular_componentdendrite membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034707cellular_componentchloride channel complex
A0038023molecular_functionsignaling receptor activity
A0043197cellular_componentdendritic spine
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0051932biological_processsynaptic transmission, GABAergic
A0060078biological_processregulation of postsynaptic membrane potential
A0098794cellular_componentpostsynapse
A0098982cellular_componentGABA-ergic synapse
A0099634cellular_componentpostsynaptic specialization membrane
A1902476biological_processchloride transmembrane transport
A1902710cellular_componentGABA receptor complex
A1902711cellular_componentGABA-A receptor complex
A1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
A1904862biological_processinhibitory synapse assembly
B0004888molecular_functiontransmembrane signaling receptor activity
B0004890molecular_functionGABA-A receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005254molecular_functionchloride channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006821biological_processchloride transport
B0007165biological_processsignal transduction
B0007214biological_processgamma-aminobutyric acid signaling pathway
B0007268biological_processchemical synaptic transmission
B0007399biological_processnervous system development
B0007420biological_processbrain development
B0007612biological_processlearning
B0007613biological_processmemory
B0009410biological_processresponse to xenobiotic stimulus
B0009986cellular_componentcell surface
B0016020cellular_componentmembrane
B0019098biological_processreproductive behavior
B0021549biological_processcerebellum development
B0022851molecular_functionGABA-gated chloride ion channel activity
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0034220biological_processmonoatomic ion transmembrane transport
B0034707cellular_componentchloride channel complex
B0035176biological_processsocial behavior
B0035640biological_processexploration behavior
B0042747biological_processcircadian sleep/wake cycle, REM sleep
B0042802molecular_functionidentical protein binding
B0043197cellular_componentdendritic spine
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0048666biological_processneuron development
B0051932biological_processsynaptic transmission, GABAergic
B0060021biological_processroof of mouth development
B0060022biological_processhard palate development
B0060080biological_processinhibitory postsynaptic potential
B0060119biological_processinner ear receptor cell development
B0060384biological_processinnervation
B0061744biological_processmotor behavior
B0071294biological_processcellular response to zinc ion
B0071420biological_processcellular response to histamine
B0072347biological_processresponse to anesthetic
B0090102biological_processcochlea development
B0098982cellular_componentGABA-ergic synapse
B0099634cellular_componentpostsynaptic specialization membrane
B1902476biological_processchloride transmembrane transport
B1902711cellular_componentGABA-A receptor complex
B1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B1904862biological_processinhibitory synapse assembly
C0004888molecular_functiontransmembrane signaling receptor activity
C0004890molecular_functionGABA-A receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0006821biological_processchloride transport
C0007214biological_processgamma-aminobutyric acid signaling pathway
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
D0004888molecular_functiontransmembrane signaling receptor activity
D0004890molecular_functionGABA-A receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005254molecular_functionchloride channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006821biological_processchloride transport
D0007214biological_processgamma-aminobutyric acid signaling pathway
D0008503molecular_functionbenzodiazepine receptor activity
D0016020cellular_componentmembrane
D0016917molecular_functionGABA receptor activity
D0022851molecular_functionGABA-gated chloride ion channel activity
D0030659cellular_componentcytoplasmic vesicle membrane
D0031410cellular_componentcytoplasmic vesicle
D0032590cellular_componentdendrite membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034707cellular_componentchloride channel complex
D0038023molecular_functionsignaling receptor activity
D0043197cellular_componentdendritic spine
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0051932biological_processsynaptic transmission, GABAergic
D0060078biological_processregulation of postsynaptic membrane potential
D0098794cellular_componentpostsynapse
D0098982cellular_componentGABA-ergic synapse
D0099634cellular_componentpostsynaptic specialization membrane
D1902476biological_processchloride transmembrane transport
D1902710cellular_componentGABA receptor complex
D1902711cellular_componentGABA-A receptor complex
D1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D1904862biological_processinhibitory synapse assembly
E0004888molecular_functiontransmembrane signaling receptor activity
E0004890molecular_functionGABA-A receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005254molecular_functionchloride channel activity
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006821biological_processchloride transport
E0007165biological_processsignal transduction
E0007214biological_processgamma-aminobutyric acid signaling pathway
E0007268biological_processchemical synaptic transmission
E0007399biological_processnervous system development
E0007420biological_processbrain development
E0007612biological_processlearning
E0007613biological_processmemory
E0009410biological_processresponse to xenobiotic stimulus
E0009986cellular_componentcell surface
E0016020cellular_componentmembrane
E0019098biological_processreproductive behavior
E0021549biological_processcerebellum development
E0022851molecular_functionGABA-gated chloride ion channel activity
E0030659cellular_componentcytoplasmic vesicle membrane
E0031410cellular_componentcytoplasmic vesicle
E0034220biological_processmonoatomic ion transmembrane transport
E0034707cellular_componentchloride channel complex
E0035176biological_processsocial behavior
E0035640biological_processexploration behavior
E0042747biological_processcircadian sleep/wake cycle, REM sleep
E0042802molecular_functionidentical protein binding
E0043197cellular_componentdendritic spine
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0048666biological_processneuron development
E0051932biological_processsynaptic transmission, GABAergic
E0060021biological_processroof of mouth development
E0060022biological_processhard palate development
E0060080biological_processinhibitory postsynaptic potential
E0060119biological_processinner ear receptor cell development
E0060384biological_processinnervation
E0061744biological_processmotor behavior
E0071294biological_processcellular response to zinc ion
E0071420biological_processcellular response to histamine
E0072347biological_processresponse to anesthetic
E0090102biological_processcochlea development
E0098982cellular_componentGABA-ergic synapse
E0099634cellular_componentpostsynaptic specialization membrane
E1902476biological_processchloride transmembrane transport
E1902711cellular_componentGABA-A receptor complex
E1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E1904862biological_processinhibitory synapse assembly
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CmMdLrrYPlDeqnC
ChainResidueDetails
BCYS136-CYS150
CCYS151-CYS165
ACYS139-CYS153

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues248
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
CGLN1-PHE236
CARG284-ALA295
CLEU434-LEU436
ELEU268-LYS279
DASN275-THR284
DTYR415-GLN429

site_idSWS_FT_FI2
Number of Residues83
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6I53
ChainResidueDetails
CTHR237-ILE257
CALA264-ALA283
CMET296-PHE320
CTYR413-TYR433
EILE222-ILE242
ESER247-HIS267
EALA280-ASN303
EILE423-TYR445

site_idSWS_FT_FI3
Number of Residues96
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
CASN258-PRO263
CVAL321-SER412
EASN243-ALA246
ETYR304-ALA422

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN13
CASN90

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29950725, ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6D6T, ECO:0007744|PDB:6I53
ChainResidueDetails
CASN208
BPHE200
EASP95
EPHE200

site_idSWS_FT_FI6
Number of Residues6
DetailsBINDING: in chain B => ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7
ChainResidueDetails
BTYR97
BSER156
BTHR202
ETYR97
ESER156
ETHR202

site_idSWS_FT_FI7
Number of Residues2
DetailsBINDING: in chain A => ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7
ChainResidueDetails
BGLU155
EGLU155

site_idSWS_FT_FI8
Number of Residues2
DetailsBINDING: in chain A => ECO:0000269|PubMed:30140029, ECO:0007744|PDB:6A96
ChainResidueDetails
BTYR157
ETYR157

site_idSWS_FT_FI9
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7
ChainResidueDetails
BASN8
EASN8

site_idSWS_FT_FI10
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:6I53, ECO:0007744|PDB:7QN7
ChainResidueDetails
BASN80
EASN80

site_idSWS_FT_FI11
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:30140029, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:6A96, ECO:0007744|PDB:6I53, ECO:0007744|PDB:7QN7
ChainResidueDetails
BASN149
EASN149

237423

PDB entries from 2025-06-11

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