6HUJ
CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with picrotoxin, GABA and megabody Mb38.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1 | polymer | 464 | 52916.6 | 2 | UniProt (P08219) UniProt (P14867) Pfam (PF02931) Pfam (PF02932) In PDB | Bos taurus (Bovine) | GABA(A) receptor subunit alpha-1,GABA(A) receptor subunit alpha-1 |
2 | B, E | Gamma-aminobutyric acid receptor subunit beta-3 | polymer | 473 | 54444.6 | 2 | UniProt (P28472) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (Human) | GABA(A) receptor subunit beta-3 |
3 | C | Gamma-aminobutyric acid receptor subunit gamma-2 | polymer | 495 | 56922.1 | 1 | UniProt (P18507) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (Human) | GABA(A) receptor subunit gamma-2 |
4 | G | Megabody Mb38 | polymer | 539 | 57784.3 | 1 | Lama glama | ||
5 | F | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G55220VL) | |||
6 | H, M | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 2 | In PDB GlyTouCan (G09724ZC) | |||
7 | I, J, L | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
8 | K | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
9 | A, D | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 2 | Chemie (PIO) | |||
10 | A | (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione | non-polymer | 292.3 | 1 | Chemie (RI5) | |||
11 | A, D | GAMMA-AMINO-BUTANOIC ACID | non-polymer | 103.1 | 2 | Chemie (ABU) |
Sequence modifications
A, D: -34 - -8 (UniProt: P08219)
A, D: 1 - 429 (UniProt: P14867)
C: -38 - 436 (UniProt: P18507)
PDB | External Database | Details |
---|---|---|
Asp -7 | - | linker |
Tyr -6 | - | linker |
Lys -5 | - | linker |
Asp -4 | - | linker |
Asp -3 | - | linker |
Asp -2 | - | linker |
Asp -1 | - | linker |
Lys 0 | - | linker |
C: -38 - 436 (UniProt: P18507)
PDB | External Database | Details |
---|---|---|
Gly 437 | - | expression tag |
Gly 438 | - | expression tag |
Ser 439 | - | expression tag |
Gly 440 | - | expression tag |
Gly 441 | - | expression tag |
Ser 442 | - | expression tag |
Gly 443 | - | expression tag |
Gly 444 | - | expression tag |
Ser 445 | - | expression tag |
Gly 446 | - | expression tag |
Lys 447 | - | expression tag |
Thr 448 | - | expression tag |
Glu 449 | - | expression tag |
Thr 450 | - | expression tag |
Ser 451 | - | expression tag |
Gln 452 | - | expression tag |
Val 453 | - | expression tag |
Ala 454 | - | expression tag |
Pro 455 | - | expression tag |
Ala 456 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 329428.7 | |
Branched | Number of molecules | 7 |
Total formula weight | 5565.1 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1991.7 | |
All* | Total formula weight | 336985.4 |