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PDB: 32 件
3BUX
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BU of 3bux by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met
分子名称: 13-meric peptide from Hepatocyte growth factor receptor, E3 ubiquitin-protein ligase CBL
著者Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J.
登録日2008-01-03
公開日2008-02-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUW
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BU of 3buw by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk
分子名称: 13-meric peptide from Tyrosine-protein kinase SYK, E3 ubiquitin-protein ligase CBL
著者Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J.
登録日2008-01-03
公開日2008-02-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
7SIY
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BU of 7siy by Molmil
cCBL TKB domain in complex with pZAP70 peptide
分子名称: E3 ubiquitin-protein ligase CBL, MAGNESIUM ION, Peptide from Tyrosine-protein kinase ZAP-70
著者Murray, J.M, Yu, C.
登録日2021-10-15
公開日2022-11-09
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献cCBL TKB domain in complex with pZAP70 peptide
To Be Published
5HKZ
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BU of 5hkz by Molmil
Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8 A Resolution (P21 form)
分子名称: E3 ubiquitin-protein ligase CBL, Protein sprouty homolog 2, SODIUM ION
著者Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P.
登録日2016-01-14
公開日2017-01-18
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8 A Resolution (P21 form)
To be published
5HKY
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BU of 5hky by Molmil
Crystal structure of c-Cbl TKBD domain in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8A Resolution (P6 form)
分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase CBL, PENTAETHYLENE GLYCOL, ...
著者Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P.
登録日2016-01-14
公開日2017-01-18
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of c-Cbl TKBD domain in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8A Resolution (P6 form)
To be published
5HKX
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BU of 5hkx by Molmil
Crystal Structure of c-Cbl TKBD-RING domains (Y371E mutant) Refined to 1.85 A Resolution
分子名称: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase CBL, SODIUM ION, ...
著者Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P.
登録日2016-01-14
公開日2017-01-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal Structure of c-Cbl TKBD-RING domains (Y371E mutant) Refined to 1.85 A Resolution
To be published
3PLF
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BU of 3plf by Molmil
Reverse Binding Mode of MetRD peptide complexed with c-Cbl TKB domain
分子名称: CALCIUM ION, CHLORIDE ION, E3 ubiquitin-protein ligase CBL, ...
著者Sun, Q, Sivaraman, J.
登録日2010-11-15
公開日2010-12-01
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding
Febs Lett., 585, 2011
2Y1N
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BU of 2y1n by Molmil
Structure of c-Cbl-ZAP-70 peptide complex
分子名称: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, TYROSINE-PROTEIN KINASE ZAP-70 ZAP-70,70 KDA ZETA-ASSOCIATED PROTEIN, ...
著者Dou, H, Sibbet, G.J, Huang, D.T.
登録日2010-12-08
公開日2012-01-18
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.999 Å)
主引用文献Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
3BUN
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BU of 3bun by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4
分子名称: 13-meric peptide from Protein sprouty homolog 4, E3 ubiquitin-protein ligase CBL
著者Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J.
登録日2008-01-03
公開日2008-02-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUM
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BU of 3bum by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2
分子名称: E3 ubiquitin-protein ligase CBL, Protein sprouty homolog 2
著者Ng, C, Jackson, A.R, Buschdorf, P.J, Sun, Q, Guy, R.G, Sivaraman, J.
登録日2008-01-03
公開日2008-02-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
1YVH
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BU of 1yvh by Molmil
Crystal Structure of the c-Cbl TKB Domain in Complex with the APS pTyr-618 Phosphopeptide
分子名称: 13-mer fragment of SH2 and PH domain-containing adapter protein APS, CBL E3 ubiquitin protein ligase, MAGNESIUM ION
著者Hu, J, Hubbard, S.R.
登録日2005-02-15
公開日2005-03-08
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural Characterization of a Novel Cbl Phosphotyrosine Recognition Motif in the APS Family of Adapter Proteins
J.Biol.Chem., 280, 2005
2CBL
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BU of 2cbl by Molmil
N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE ON ZAP-70
分子名称: CALCIUM ION, PROTO-ONCOGENE CBL, ZAP-70
著者Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J.
登録日1998-08-28
公開日1999-05-18
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature, 398, 1999
2OO9
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BU of 2oo9 by Molmil
crystal structure of the UBA domain from human c-Cbl ubiquitin ligase
分子名称: E3 ubiquitin-protein ligase CBL
著者Kozlov, G, Gehring, K.
登録日2007-01-25
公開日2007-02-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase.
J.Biol.Chem., 282, 2007
3OB2
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BU of 3ob2 by Molmil
Crystal structure of c-Cbl TKB domain in complex with double phosphorylated EGFR peptide
分子名称: 12-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL
著者Sun, Q, Sivaraman, J.
登録日2010-08-06
公開日2010-08-18
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain
Plos One, 5, 2010
5HL0
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BU of 5hl0 by Molmil
Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (54-60, pY55) Refined to 2.2A Resolution
分子名称: E3 ubiquitin-protein ligase CBL, SODIUM ION, Sprouty 2 (SPRY2)
著者Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P.
登録日2016-01-14
公開日2017-01-18
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (54-60, pY55) Refined to 2.2A Resolution
To Be Published
1B47
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BU of 1b47 by Molmil
STRUCTURE OF THE N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE IN ZAP-70
分子名称: CALCIUM ION, CBL
著者Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J.
登録日1999-01-06
公開日1999-04-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature, 398, 1999
3OB1
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BU of 3ob1 by Molmil
Crystal structure of c-Cbl TKB domain in complex with double phosphorylated Spry2 peptide
分子名称: 12-meric peptide from Protein sprouty homolog 2, E3 ubiquitin-protein ligase CBL
著者Sun, Q, Sivaraman, J.
登録日2010-08-06
公開日2010-08-18
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain
Plos One, 5, 2010
4A49
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BU of 4a49 by Molmil
Structure of phosphoTyr371-c-Cbl-UbcH5B complex
分子名称: E3 ubiquitin-protein ligase CBL, POTASSIUM ION, Ubiquitin-conjugating enzyme E2 D2, ...
著者Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T.
登録日2011-10-07
公開日2012-01-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.214 Å)
主引用文献Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.
Nat. Struct. Mol. Biol., 19, 2012
5HKW
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BU of 5hkw by Molmil
Crystal Structure of Apo c-Cbl TKBD Refined to 2.25 A Resolution
分子名称: E3 ubiquitin-protein ligase CBL, SODIUM ION
著者Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P.
登録日2016-01-14
公開日2017-01-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal Structure of Apo c-Cbl TKBD Refined to 2.25 A Resolution
To be published
5O76
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BU of 5o76 by Molmil
Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant
分子名称: CALCIUM ION, E3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, ...
著者Gabrielsen, M, Buetow, L, Huang, D.T.
登録日2017-06-08
公開日2017-11-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.473 Å)
主引用文献A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
6XAR
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BU of 6xar by Molmil
Structure of CBL tyrosine kinase binding domain (TKBD) with C-terminal tail of Src-like kinase protein 2 (SLAP2)
分子名称: CALCIUM ION, E3 ubiquitin-protein ligase CBL, Src-like-adapter 2
著者Wybenga-Groot, L.E, McGlade, C.J.
登録日2020-06-04
公開日2021-03-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function.
J.Mol.Biol., 433, 2021
3BUO
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BU of 3buo by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'
分子名称: 13-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL
著者Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J.
登録日2008-01-03
公開日2008-02-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
2Y1M
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BU of 2y1m by Molmil
Structure of native c-Cbl
分子名称: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, ZINC ION
著者Dou, H, Sibbet, G.J, Huang, D.T.
登録日2010-12-08
公開日2012-01-18
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
4A4C
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BU of 4a4c by Molmil
Structure of phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex
分子名称: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, ...
著者Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T.
登録日2011-10-08
公開日2012-01-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.704 Å)
主引用文献Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19, 2012
4A4B
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BU of 4a4b by Molmil
Structure of modified phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex
分子名称: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, ...
著者Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T.
登録日2011-10-08
公開日2012-01-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.789 Å)
主引用文献Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19, 2012

 

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