4NGE
 
 | | Crystal Structure of Human Presequence Protease in Complex with Amyloid-beta (1-40) | | 分子名称: | ACETATE ION, Beta-amyloid protein 40, GLYCEROL, ... | | 著者 | King, J.V, Liang, W.G, Tang, W.J. | | 登録日 | 2013-11-01 | | 公開日 | 2014-05-14 | | 最終更新日 | 2014-07-23 | | 実験手法 | X-RAY DIFFRACTION (2.704 Å) | | 主引用文献 | Molecular basis of substrate recognition and degradation by human presequence protease.
Structure, 22, 2014
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8C3H
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3MXC
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3MXY
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4ONF
 | | Fab fragment of 3D6 in complex with amyloid beta 1-7 | | 分子名称: | 3D6 FAB ANTIBODY HEAVY CHAIN, 3D6 FAB ANTIBODY LIGHT CHAIN, Amyloid beta A4 protein | | 著者 | Feinberg, H, Saldanha, J.W, Diep, L, Goel, A, Widom, A, Veldman, G.M, Weis, W.I, Schenk, D, Basi, G.S. | | 登録日 | 2014-01-28 | | 公開日 | 2014-06-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab.
Alzheimers Res Ther, 6, 2014
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4OJF
 | | Humanised 3D6 Fab complexed to amyloid beta 1-8 | | 分子名称: | Amyloid beta A4 protein, Humanised 3D6 Fab Heavy Chain, Humanised 3D6 Fab Light Chain | | 著者 | Miles, L.A, Crespi, G.A.N, Parker, M.W. | | 登録日 | 2014-01-21 | | 公開日 | 2015-01-28 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.998 Å) | | 主引用文献 | Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-beta
ACTA CRYSTALLOGR.,SECT.F, 70, 2014
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3NYJ
 | | Crystal Structure Analysis of APP E2 domain | | 分子名称: | Amyloid beta A4 protein, OSMIUM ION | | 著者 | Ha, Y, Hu, J, Lee, S, Liu, X. | | 登録日 | 2010-07-15 | | 公開日 | 2011-06-01 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization.
Biochemistry, 50, 2011
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3NYL
 | | The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain | | 分子名称: | Amyloid beta (A4) protein (Peptidase nexin-II, Alzheimer disease), isoform CRA_b | | 著者 | Ha, Y, Hu, J, Lee, S, Liu, X, Wang, Y. | | 登録日 | 2010-07-15 | | 公開日 | 2011-07-13 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain.
Mol.Cell, 15, 2004
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8AZT
 | | Type II amyloid-beta 42 filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | ABeta42 | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Yang, Y, Stern, M.A, Meunier, L.A, Liu, W, Cai, Y.Q, Ericsson, M, Liu, L, Selkoe, J.D, Goedert, M, Scheres, H.W.S. | | 登録日 | 2022-09-06 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Abundant A beta fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains.
Neuron, 111, 2023
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8AZS
 | | Type I amyloid-beta 42 filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | ABeta42 | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Yang, Y, Stern, M.A, Meunier, L.A, Liu, W, Cai, Y.Q, Ericsson, M, Liu, L, Selkoe, J.D, Goedert, M, Scheres, H.W.S. | | 登録日 | 2022-09-06 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Abundant A beta fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains.
Neuron, 111, 2023
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3KTM
 | | Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP) | | 分子名称: | (3R)-butane-1,3-diol, ACETATE ION, Amyloid beta A4 protein, ... | | 著者 | Dahms, S.O, Hoefgen, S, Roeser, D, Schlott, B, Guhrs, K.H, Than, M.E. | | 登録日 | 2009-11-25 | | 公開日 | 2010-02-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein.
Proc.Natl.Acad.Sci.USA, 107, 2010
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8BG0
 | | Amyloid-beta tetrameric filaments with the Arctic mutation (E22G) from Alzheimer's disease brains | ABeta40 | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W. | | 登録日 | 2022-10-27 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (1.99 Å) | | 主引用文献 | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains.
Acta Neuropathol, 145, 2023
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8BFZ
 | | Amyloid-beta 42 filaments extracted from the human brain with Arctic mutation (E22G) of Alzheimer's disease | ABeta42 | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordberg, A, Goedert, M, Scheres, S.H.W. | | 登録日 | 2022-10-27 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains.
Acta Neuropathol, 145, 2023
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3OVJ
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8B9R
 | | Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease | | 分子名称: | Amyloid-beta A4 protein, COPPER (II) ION | | 著者 | Abelein, A, Ciofi-Baffoni, S, Morman, C, Kumar, R, Giachetti, A, Piccioli, M, Biverstal, H. | | 登録日 | 2022-10-06 | | 公開日 | 2023-02-01 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Molecular Structure of Cu(II)-Bound Amyloid-beta Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease.
Jacs Au, 2, 2022
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8BFB
 | | Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure (Methoxy-X04-labelled mice) | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Wilkinson, M, Leistner, C, Burgess, A, Goodfellow, S, Deuchars, S, Ranson, N.A, Radford, S.E, Frank, R.A.W. | | 登録日 | 2022-10-24 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain.
Nat Commun, 14, 2023
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8BFA
 | | Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Wilkinson, M, Leistner, C, Burgess, A, Goodfellow, S, Deuchars, S, Ranson, N.A, Radford, S.E, Frank, R.A.W. | | 登録日 | 2022-10-24 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain.
Nat Commun, 14, 2023
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8B9Q
 | | Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease | | 分子名称: | Amyloid-beta A4 protein, COPPER (II) ION | | 著者 | Abelein, A, Ciofi-Baffoni, S, Kumar, R, Giachetti, A, Piccioli, M, Biverstal, H. | | 登録日 | 2022-10-06 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Molecular Structure of Cu(II)-Bound Amyloid-beta Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease.
Jacs Au, 2, 2022
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3L81
 | | Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP) | | 分子名称: | AP-4 complex subunit mu-1, Amyloid beta A4 protein, GLYCEROL | | 著者 | Mardones, G.A, Rojas, A.L, Burgos, P.V, Dasilva, L.L.P, Prabhu, Y, Bonifacino, J.S, Hurley, J.H. | | 登録日 | 2009-12-29 | | 公開日 | 2010-06-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex.
Dev.Cell, 18, 2010
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3PZZ
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3OW9
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3Q2X
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9CZN
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8X53
 | | Cryo-EM structure of human gamma-secretase in complex with Abeta46 | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y. | | 登録日 | 2023-11-16 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Molecular mechanism of substrate recognition and cleavage by human gamma-secretase.
Science, 384, 2024
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3IFN
 | | X-ray structure of amyloid beta peptide:antibody (Abeta1-40:12A11) complex | | 分子名称: | 12A11 FAB antibody heavy chain, 12A11 FAB antibody light chain, Amyloid beta A4 protein | | 著者 | Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D. | | 登録日 | 2009-07-24 | | 公開日 | 2009-11-17 | | 最終更新日 | 2013-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J.Biol.Chem., 285, 2010
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