8ORE
 
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7YPG
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8Q8X
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8Q9I
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7QKU
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7R5H
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6DCA
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8TTL
 | | AT8-Phosphomimetic Tau Filaments (Full-length, Cofactor-Free 0N4R Tau S202E, T205E, S208E) | | 分子名称: | Microtubule-associated protein tau | | 著者 | El Mammeri, N, Dregni, A.J, Duan, P, Hong, M. | | 登録日 | 2023-08-14 | | 公開日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7KQK
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8OH2
 | | Structure of the Tau-PAM4 Type 1 amyloid fibril | | 分子名称: | Microtubule-associated protein tau | | 著者 | Wilkinson, M, Louros, N, Tsaka, G, Ramakers, M, Morelli, C, Garcia, T, Gallardo, R.U, D'Haeyer, S, Goossens, V, Audenaert, D, Thal, D.R, Ranson, N.A, Radford, S.E, Rousseau, F, Schymkowitz, J. | | 登録日 | 2023-03-20 | | 公開日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Local structural preferences in shaping tau amyloid polymorphism.
Nat Commun, 15, 2024
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8BYN
 | | Chronic traumatic encephalopathy tau filaments with PET ligand flortaucipir | | 分子名称: | 7-(6-fluoranylpyridin-3-yl)-5~{H}-pyrido[4,3-b]indole, Microtubule-associated protein tau | | 著者 | Shi, Y, Ghetti, B, Goedert, M, Scheres, S.H.W. | | 登録日 | 2022-12-13 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-11-01 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Cryo-EM Structures of Chronic Traumatic Encephalopathy Tau Filaments with PET Ligand Flortaucipir.
J.Mol.Biol., 435, 2023
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5ZIA
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7QK2
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8P34
 | | Tau filaments extracted from human brain with the DeltaK281 mutation in MAPT | | 分子名称: | Microtubule-associated protein tau | | 著者 | Schweighauser, M, Garringer, H.J, Klingstedt, T, Masuda-Suzukake, M, Murrell, J.R, Vidal, R, Scheres, S.H.W, Goedert, M, Ghetti, B, Newell, K.L. | | 登録日 | 2023-05-17 | | 公開日 | 2023-07-05 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | Mutation ∆K281 in MAPT causes Pick's disease.
Acta Neuropathol, 146, 2023
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6H06
 | | FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5 | | 分子名称: | GLYCEROL, HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-22.1, HUMAN FAB ANTIBODY FRAGMENT OF HCBTAU-22.1, ... | | 著者 | Juraszek, J, Steinbacher, S. | | 登録日 | 2018-07-06 | | 公開日 | 2018-07-25 | | 最終更新日 | 2020-03-11 | | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | | 主引用文献 | Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422containing epitope on pathological tau.
Acta Neuropathol Commun, 6, 2018
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8Q9G
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8Q9M
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7QKZ
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7QKM
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8Q8S
 | | Tau - AD-THF | | 分子名称: | Isoform Tau-D of Microtubule-associated protein tau | | 著者 | Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. | | 登録日 | 2023-08-18 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | | 主引用文献 | Disease-specific tau filaments assemble via polymorphic intermediates.
Nature, 625, 2024
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7NRS
 | | Conformation 1 of straight filament from primary age-related tauopathy brain | | 分子名称: | Microtubule-associated protein tau | | 著者 | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | | 登録日 | 2021-03-04 | | 公開日 | 2021-03-24 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | | 主引用文献 | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
Acta Neuropathol, 141, 2021
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7NRT
 | | Conformation 2 of straight filament from primary age-related tauopathy brain | | 分子名称: | Microtubule-associated protein tau | | 著者 | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | | 登録日 | 2021-03-04 | | 公開日 | 2021-03-24 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | | 主引用文献 | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
Acta Neuropathol, 141, 2021
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8Q99
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8OTI
 | | CTE typeIII tau filament | | 分子名称: | Microtubule-associated protein tau | | 著者 | Tetter, S, Qi, C, Ryskeldi-Falcon, B, Scheres, S.H.W, Goedert, M. | | 登録日 | 2023-04-20 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7P65
 | | Progressive supranuclear palsy tau filament | | 分子名称: | Microtubule-associated protein tau | | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | | 登録日 | 2021-07-15 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structure-based classification of tauopathies.
Nature, 598, 2021
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