8OH2
Structure of the Tau-PAM4 Type 1 amyloid fibril
Summary for 8OH2
Entry DOI | 10.2210/pdb8oh2/pdb |
EMDB information | 16876 |
Descriptor | Microtubule-associated protein tau (2 entities in total) |
Functional Keywords | amyloid, tau, helical, cross-beta, fibril, neurodegeneration, protein fibril |
Biological source | synthetic construct |
Total number of polymer chains | 36 |
Total formula weight | 51754.39 |
Authors | Wilkinson, M.,Louros, N.,Tsaka, G.,Ramakers, M.,Morelli, C.,Garcia, T.,Gallardo, R.U.,D'Haeyer, S.,Goossens, V.,Audenaert, D.,Thal, D.R.,Ranson, N.A.,Radford, S.E.,Rousseau, F.,Schymkowitz, J. (deposition date: 2023-03-20, release date: 2024-02-21) |
Primary citation | Louros, N.,Wilkinson, M.,Tsaka, G.,Ramakers, M.,Morelli, C.,Garcia, T.,Gallardo, R.,D'Haeyer, S.,Goossens, V.,Audenaert, D.,Thal, D.R.,Mackenzie, I.R.,Rademakers, R.,Ranson, N.A.,Radford, S.E.,Rousseau, F.,Schymkowitz, J. Local structural preferences in shaping tau amyloid polymorphism. Nat Commun, 15:1028-1028, 2024 Cited by PubMed: 38310108DOI: 10.1038/s41467-024-45429-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.6 Å) |
Structure validation
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