8ORE

Cryo-EM structure of SH-SY5Y seeded with filaments from Alzheimer's Disease

Summary for 8ORE

• Entry DOI: 10.2210/pdb8ore/pdb
• EMDB information: 17121
• Descriptor: Microtubule-associated protein tau (1 entity in total)
• Functional Keywords: amyloid, tau, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 119346.20

Authors

Lovestam, S.,Scheres, S.H.W.,Goedert, M. (deposition date: 2023-04-13, release date: 2023-04-26, Last modification date: 2023-08-09)

• Primary citation: Tarutani, A.,Lovestam, S.,Zhang, X.,Kotecha, A.,Robinson, A.C.,Mann, D.M.A.,Saito, Y.,Murayama, S.,Tomita, T.,Goedert, M.,Scheres, S.H.W.,Hasegawa, M.; Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration.; Febs Open Bio, 13:1394-1404, 2023; PubMed: 37337995; DOI: 10.1002/2211-5463.13657

Experimental method

ELECTRON MICROSCOPY (2.5 Å)