8ORE
Cryo-EM structure of SH-SY5Y seeded with filaments from Alzheimer's Disease
Functional Information from GO Data
Functional Information from PROSITE/UniProt
site_id | PS00229 |
Number of Residues | 13 |
Details | TAU_MAP_1 Tau and MAP proteins tubulin-binding repeat signature. GSteNlkHqPGGG |
Chain | Residue | Details |
A | GLY261-GLY273 | |
A | GLY323-GLY335 | |
A | GLY355-GLY367 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 84 |
Details | SITE: Not glycated => ECO:0000269|PubMed:9326300 |
Chain | Residue | Details |
A | LYS274 | |
A | LYS321 | |
A | LEU325 | |
A | HIS329 | |
A | GLU342 | |
A | ASP348 | |
A | SER352 | |
A | HIS362 | |
A | ILE371 | |
A | HIS374 | |
A | GLY401 | |
A | ARG406 | |
A | THR414 | |
A | SER416 | |
A | ALA426 | |
B | LYS53 | |
B | LYS73 | |
B | LYS96 | |
B | LEU441 | |
B | LYS148 | |
B | LYS180 | |
B | LYS190 | |
B | LYS224 | |
B | LYS240 | |
B | LYS254 | |
B | LYS257 | |
B | LYS267 | |
B | LYS274 | |
B | LYS321 | |
B | LEU325 | |
B | HIS329 | |
B | GLU342 | |
B | ASP348 | |
B | SER352 | |
B | HIS362 | |
B | ILE371 | |
B | HIS374 | |
B | GLY401 | |
B | ARG406 | |
B | THR414 | |
B | SER416 | |
B | ALA426 | |
C | LYS53 | |
C | LYS73 | |
C | LYS96 | |
C | LEU441 | |
C | LYS148 | |
C | LYS180 | |
C | LYS190 | |
C | LYS224 | |
C | LYS240 | |
C | LYS254 | |
C | LYS257 | |
C | LYS267 | |
C | LYS274 | |
C | LYS321 | |
C | LEU325 | |
C | HIS329 | |
C | GLU342 | |
C | ASP348 | |
C | SER352 | |
C | HIS362 | |
C | ILE371 | |
C | HIS374 | |
C | GLY401 | |
C | ARG406 | |
C | THR414 | |
C | SER416 | |
C | ALA426 | |
A | LYS254 | |
A | LYS257 | |
A | LYS148 | |
A | LYS180 | |
A | LYS190 | |
A | LYS224 | |
A | LYS240 | |
A | LYS267 | |
A | LYS53 | |
A | LYS73 | |
A | LYS96 | |
A | LEU441 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:1512244 |
Chain | Residue | Details |
A | ALA31 | |
B | ALA31 | |
C | ALA31 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | MOD_RES: Phosphotyrosine; by FYN => ECO:0000269|PubMed:14999081 |
Chain | Residue | Details |
A | TYR47 | |
B | TYR47 | |
C | TYR47 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P10637 |
Chain | Residue | Details |
B | LEU425 | |
C | TYR58 | |
C | LEU425 | |
A | LEU425 | |
B | TYR58 | |
A | TYR58 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P19332 |
Chain | Residue | Details |
A | SER75 | |
A | SER90 | |
B | SER75 | |
B | SER90 | |
C | SER75 | |
C | SER90 |
site_id | SWS_FT_FI6 |
Number of Residues | 15 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P10637 |
Chain | Residue | Details |
B | LYS140 | |
B | THR169 | |
B | THR175 | |
B | ALA434 | |
C | THR98 | |
C | LYS140 | |
C | THR169 | |
C | THR175 | |
C | ALA434 | |
A | THR169 | |
A | THR175 | |
A | ALA434 | |
B | THR98 | |
A | THR98 | |
A | LYS140 |
site_id | SWS_FT_FI7 |
Number of Residues | 3 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P19332 |
Chain | Residue | Details |
A | THR100 | |
B | THR100 | |
C | THR100 |
site_id | SWS_FT_FI8 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine; by SGK1 => ECO:0000269|PubMed:16982696 |
Chain | Residue | Details |
A | LEU243 | |
B | LEU243 | |
C | LEU243 |
site_id | SWS_FT_FI9 |
Number of Residues | 3 |
Details | MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:9614189 |
Chain | Residue | Details |
A | THR153 | |
B | THR153 | |
C | THR153 |
site_id | SWS_FT_FI10 |
Number of Residues | 6 |
Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P10637 |
Chain | Residue | Details |
A | GLU380 | |
B | GLU380 | |
C | GLU380 | |
A | ARG155 | |
B | ARG155 | |
C | ARG155 |
site_id | SWS_FT_FI11 |
Number of Residues | 33 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P10637 |
Chain | Residue | Details |
A | LYS163 | |
A | PRO312 | |
A | HIS329 | |
A | GLU342 | |
A | ASP348 | |
A | SER352 | |
A | HIS362 | |
A | HIS374 | |
A | PHE378 | |
A | SER400 | |
A | SER416 | |
B | LYS163 | |
B | PRO312 | |
B | HIS329 | |
B | GLU342 | |
B | ASP348 | |
B | SER352 | |
B | HIS362 | |
B | HIS374 | |
B | PHE378 | |
B | SER400 | |
B | SER416 | |
C | LYS163 | |
C | PRO312 | |
C | HIS329 | |
C | GLU342 | |
C | ASP348 | |
C | SER352 | |
C | HIS362 | |
C | HIS374 | |
C | PHE378 | |
C | SER400 | |
C | SER416 |
site_id | SWS_FT_FI12 |
Number of Residues | 6 |
Details | MOD_RES: Deamidated asparagine; in tau and PHF-tau; partial => ECO:0000269|PubMed:1512244 |
Chain | Residue | Details |
A | ASN167 | |
A | TYR310 | |
B | ASN167 | |
B | TYR310 | |
C | ASN167 | |
C | TYR310 |
site_id | SWS_FT_FI13 |
Number of Residues | 3 |
Details | MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:15546861 |
Chain | Residue | Details |
A | THR181 | |
B | THR181 | |
C | THR181 |
site_id | SWS_FT_FI14 |
Number of Residues | 9 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P10637 |
Chain | Residue | Details |
A | SER185 | |
A | SER191 | |
A | SER195 | |
B | SER185 | |
B | SER191 | |
B | SER195 | |
C | SER185 | |
C | SER191 | |
C | SER195 |
site_id | SWS_FT_FI15 |
Number of Residues | 3 |
Details | MOD_RES: Phosphotyrosine; by TTBK1 => ECO:0000269|PubMed:16923168 |
Chain | Residue | Details |
A | TYR197 | |
B | TYR197 | |
C | TYR197 |
site_id | SWS_FT_FI16 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:16923168 |
Chain | Residue | Details |
A | SER198 | |
B | SER198 | |
C | SER198 |
site_id | SWS_FT_FI17 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189 |
Chain | Residue | Details |
A | SER199 | |
B | SER199 | |
C | SER199 |
site_id | SWS_FT_FI18 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine; by CK1, PDPK1 and TTBK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER202 | |
B | SER202 | |
C | SER202 |
site_id | SWS_FT_FI19 |
Number of Residues | 3 |
Details | MOD_RES: Phosphothreonine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179 |
Chain | Residue | Details |
A | THR205 | |
B | THR205 | |
C | THR205 |
site_id | SWS_FT_FI20 |
Number of Residues | 3 |
Details | MOD_RES: Phosphothreonine; by BRSK1, BRSK2, DYRK2 and PDPK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:9614189 |
Chain | Residue | Details |
A | THR212 | |
B | THR212 | |
C | THR212 |
site_id | SWS_FT_FI21 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189 |
Chain | Residue | Details |
A | SER214 | |
B | SER214 | |
C | SER214 |
site_id | SWS_FT_FI22 |
Number of Residues | 3 |
Details | MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179 |
Chain | Residue | Details |
A | THR217 | |
B | THR217 | |
C | THR217 |
site_id | SWS_FT_FI23 |
Number of Residues | 6 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P10637 |
Chain | Residue | Details |
A | LYS225 | |
A | LYS321 | |
B | LYS225 | |
B | LYS321 | |
C | LYS225 | |
C | LYS321 |
site_id | SWS_FT_FI24 |
Number of Residues | 3 |
Details | MOD_RES: Phosphothreonine; by GSK3-beta and PDPK1 => ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | THR231 | |
B | THR231 | |
C | THR231 |
site_id | SWS_FT_FI25 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine; by PDPK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER235 | |
B | SER235 | |
C | SER235 |
site_id | SWS_FT_FI26 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:8999860 |
Chain | Residue | Details |
A | SER237 | |
B | SER237 | |
C | SER237 |
site_id | SWS_FT_FI27 |
Number of Residues | 3 |
Details | MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P10637 |
Chain | Residue | Details |
A | LYS259 | |
B | LYS259 | |
C | LYS259 |
site_id | SWS_FT_FI28 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine; by MARK1, MARK2, MARK3, MARK4, BRSK1, BRSK2 and PHK => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:7706316, ECO:0000269|PubMed:8999860, ECO:0000269|PubMed:9614189 |
Chain | Residue | Details |
A | SER262 | |
B | SER262 | |
C | SER262 |
site_id | SWS_FT_FI29 |
Number of Residues | 6 |
Details | MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:8999860 |
Chain | Residue | Details |
A | SER316 | |
A | LYS383 | |
B | SER316 | |
B | LYS383 | |
C | SER316 | |
C | LYS383 |
site_id | SWS_FT_FI30 |
Number of Residues | 9 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:7706316 |
Chain | Residue | Details |
A | SER324 | |
A | GLY355 | |
A | ASP387 | |
B | SER324 | |
B | GLY355 | |
B | ASP387 | |
C | SER324 | |
C | GLY355 | |
C | ASP387 |
site_id | SWS_FT_FI31 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:7706316, ECO:0000269|PubMed:8999860 |
Chain | Residue | Details |
A | GLN336 | |
B | GLN336 | |
C | GLN336 |
site_id | SWS_FT_FI32 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | THR427 | |
B | THR427 | |
C | THR427 |
site_id | SWS_FT_FI33 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine; alternate => ECO:0007744|PubMed:19690332 |
Chain | Residue | Details |
A | GLU431 | |
B | GLU431 | |
C | GLU431 |
site_id | SWS_FT_FI34 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER435 | |
B | SER435 | |
C | SER435 |
site_id | SWS_FT_FI35 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:15546861, ECO:0007744|PubMed:19690332 |
Chain | Residue | Details |
A | GLY440 | |
B | GLY440 | |
C | GLY440 |
site_id | SWS_FT_FI36 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine; by CaMK2 and TTBK1 => ECO:0000269|PubMed:16923168 |
Chain | Residue | Details |
site_id | SWS_FT_FI37 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189 |
Chain | Residue | Details |
site_id | SWS_FT_FI38 |
Number of Residues | 3 |
Details | MOD_RES: Phosphothreonine; by TTBK1 => ECO:0000269|PubMed:16923168 |
Chain | Residue | Details |
site_id | SWS_FT_FI39 |
Number of Residues | 36 |
Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro => ECO:0000269|PubMed:9326300 |
Chain | Residue | Details |
A | ASP116 | |
A | LYS150 | |
A | LYS163 | |
A | LYS174 | |
A | LYS225 | |
A | LYS234 | |
A | LYS259 | |
A | LYS311 | |
A | PRO312 | |
A | PHE378 | |
A | ALA384 | |
A | SER400 | |
B | ASP116 | |
B | LYS150 | |
B | LYS163 | |
B | LYS174 | |
B | LYS225 | |
B | LYS234 | |
B | LYS259 | |
B | LYS311 | |
B | PRO312 | |
B | PHE378 | |
B | ALA384 | |
B | SER400 | |
C | ASP116 | |
C | LYS150 | |
C | LYS163 | |
C | LYS174 | |
C | LYS225 | |
C | LYS234 | |
C | LYS259 | |
C | LYS311 | |
C | PRO312 | |
C | PHE378 | |
C | ALA384 | |
C | SER400 |
site_id | SWS_FT_FI40 |
Number of Residues | 6 |
Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:21327254 |
Chain | Residue | Details |
A | SER208 | |
A | SER238 | |
B | SER208 | |
B | SER238 | |
C | SER208 | |
C | SER238 |
site_id | SWS_FT_FI41 |
Number of Residues | 3 |
Details | CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000269|PubMed:21327254 |
Chain | Residue | Details |
A | GLU431 | |
B | GLU431 | |
C | GLU431 |
site_id | SWS_FT_FI42 |
Number of Residues | 9 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P10637 |
Chain | Residue | Details |
A | LYS73 | |
A | LYS267 | |
A | ARG406 | |
B | LYS73 | |
B | LYS267 | |
B | ARG406 | |
C | LYS73 | |
C | LYS267 | |
C | ARG406 |
site_id | SWS_FT_FI43 |
Number of Residues | 33 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P10637 |
Chain | Residue | Details |
A | LYS259 | |
A | PRO312 | |
A | HIS329 | |
A | ASP348 | |
A | SER352 | |
A | HIS362 | |
A | HIS374 | |
A | PHE378 | |
A | SER400 | |
A | SER416 | |
B | LYS259 | |
B | PRO312 | |
B | HIS329 | |
B | ASP348 | |
B | SER352 | |
B | HIS362 | |
B | HIS374 | |
B | PHE378 | |
B | SER400 | |
B | SER416 | |
C | LYS259 | |
C | PRO312 | |
C | HIS329 | |
C | ASP348 | |
C | SER352 | |
C | HIS362 | |
C | HIS374 | |
C | PHE378 | |
C | SER400 | |
C | SER416 |
site_id | SWS_FT_FI44 |
Number of Residues | 9 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau => ECO:0000269|PubMed:16443603 |
Chain | Residue | Details |
A | LYS254 | |
A | GLU342 | |
A | ALA384 | |
B | LYS254 | |
B | GLU342 | |
B | ALA384 | |
C | LYS254 | |
C | GLU342 | |
C | ALA384 |