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PDB: 106 件
5W0R
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BU of 5w0r by Molmil
Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with cacodylic acid
分子名称: CACODYLATE ION, CALCIUM ION, MBP fused activation-induced cytidine deaminase, ...
著者Qiao, Q, Wang, L, Wu, H.
登録日2017-05-31
公開日2017-08-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献AID Recognizes Structured DNA for Class Switch Recombination.
Mol. Cell, 67, 2017
6YBJ
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BU of 6ybj by Molmil
Structure of MBP-Mcl-1 in complex with compound 3e
分子名称: (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[(2-methylpyrazol-3-yl)methoxy]phenyl]propanoic acid, CHLORIDE ION, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, ...
著者Dokurno, P, Surgenor, A.E, Murray, J.B.
登録日2020-03-17
公開日2020-11-18
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor.
J.Med.Chem., 63, 2020
4RAV
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BU of 4rav by Molmil
Crystal structure of scFvC4 in complex with the first 17 AA of huntingtin
分子名称: Huntingtin, SULFATE ION, Single-chain Fv, ...
著者De Genst, E, Chirgadze, D.Y, Dobson, C.M.
登録日2014-09-11
公開日2015-07-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of a single-chain fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression.
J.Mol.Biol., 427, 2015
6N85
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BU of 6n85 by Molmil
Resistance to inhibitors of cholinesterase 8A (Ric8A) protein in complex with MBP-tagged transducin-alpha residues 327-350
分子名称: Maltose/maltodextrin-binding periplasmic protein,Guanine nucleotide-binding protein G(t) subunit alpha-2, Synembryn-A, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Srivastava, D, Gakhar, L, Artemyev, N.O.
登録日2018-11-28
公開日2019-07-10
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural underpinnings of Ric8A function as a G-protein alpha-subunit chaperone and guanine-nucleotide exchange factor.
Nat Commun, 10, 2019
6QYN
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BU of 6qyn by Molmil
Structure of MBP-Mcl-1 in complex with compound 10d
分子名称: (2~{R})-2-[5-(3-chloranyl-2-methyl-4-oxidanyl-phenyl)-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]oxy-3-phenyl-propanoic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Dokurno, P, Szlavik, Z, Ondi, L, Csekei, M, Paczal, A, Szabo, Z.B, Radics, G, Murray, J, Davidson, J, Chen, I, Davis, B, Hubbard, R.E, Pedder, C, Surgenor, A.E, Smith, J, Robertson, A, LeToumelin-Braizat, G, Cauquil, N, Zarka, M, Demarles, D, Perron-Sierra, F, Geneste, O, Kotschy, A.
登録日2019-03-09
公開日2019-08-07
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity.
J.Med.Chem., 62, 2019
3LRH
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BU of 3lrh by Molmil
Structure of anti-huntingtin VL domain in complex with huntingtin peptide
分子名称: Huntingtin, anti-huntingtin VL domain
著者Schiefner, A, Chatwell, L, Skerra, A.
登録日2010-02-11
公開日2011-02-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A Disulfide-Free Single-Domain V(L) Intrabody with Blocking Activity towards Huntingtin Reveals a Novel Mode of Epitope Recognition.
J.Mol.Biol., 414, 2011
8VLX
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BU of 8vlx by Molmil
HTT in complex with HAP40 and a small molecule.
分子名称: 40-kDa huntingtin-associated protein, Huntingtin, N-[(1S,2R)-2-benzylcyclopentyl]-N'-{1-[(1S)-1-(pyridin-4-yl)ethyl]piperidin-4-yl}urea
著者Poweleit, N, Boudet, J, Doherty, E.
登録日2024-01-12
公開日2024-03-06
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Discovery of a Small Molecule Ligand to the Huntingtin/HAP40 complex
To Be Published
4XAI
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BU of 4xai by Molmil
Crystal Structure of red flour beetle NR2E1/TLX
分子名称: Grunge, isoform J, Maltose-binding periplasmic protein,Tailless ortholog, ...
著者Zhi, X, Zhou, E, Xu, E.
登録日2014-12-14
公開日2015-03-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for corepressor assembly by the orphan nuclear receptor TLX.
Genes Dev., 29, 2015
6X9O
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BU of 6x9o by Molmil
High resolution cryoEM structure of huntingtin in complex with HAP40
分子名称: 40-kDa huntingtin-associated protein, Huntingtin
著者Harding, R.J, Deme, J.C, Lea, S.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
登録日2020-06-03
公開日2020-06-17
最終更新日2022-03-30
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1.
Commun Biol, 4, 2021
8W15
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BU of 8w15 by Molmil
HTT in complex with HAP40 in the apo state.
分子名称: 40-kDa huntingtin-associated protein, Huntingtin
著者Poweleit, N, Boudet, J, Doherty, E.
登録日2024-02-15
公開日2024-03-13
実験手法ELECTRON MICROSCOPY (2.72 Å)
主引用文献Discovery of a Small Molecule Ligand to the Huntingtin/HAP40 complex
To Be Published
6DKS
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BU of 6dks by Molmil
Structure of the Rbpj-SHARP-DNA Repressor Complex
分子名称: DNA (5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*T)-3'), DNA (5'-D(*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3'), Maltose/maltodextrin-binding periplasmic protein, ...
著者Kovall, R.A, VanderWielen, B.D, Yuan, Z.
登録日2018-05-30
公開日2019-01-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site.
Cell Rep, 26, 2019
5EDU
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BU of 5edu by Molmil
Crystal structure of human histone deacetylase 6 catalytic domain 2 in complex with trichostatin A
分子名称: Maltose-binding periplasmic protein, Histone deacetylase 6 chimera, POTASSIUM ION, ...
著者Hai, Y, Christianson, D.W.
登録日2015-10-22
公開日2016-07-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
Nat.Chem.Biol., 12, 2016
5V6Y
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BU of 5v6y by Molmil
Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and altered selectivity adrenomedullin variant
分子名称: ADM, Maltose-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Pioszak, A, Booe, J.
登録日2017-03-17
公開日2018-01-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists.
Mol. Pharmacol., 93, 2018
5E7U
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BU of 5e7u by Molmil
MBP-MamC loop structure, a magnetite biomineralizing protein from Magnetospirillium magneticum AMB-1
分子名称: Maltose-binding periplasmic protein,Tightly bound bacterial magnetic particle protein,Maltose-binding periplasmic protein, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Nudelman, H, Zarivach, R.
登録日2015-10-13
公開日2016-03-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献MBP-MamC loop structure, a magnetite biomineralizing protein from Magnetospirillium magneticum AMB-1
To Be Published
4FEB
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BU of 4feb by Molmil
Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta)
分子名称: Maltose-binding periplasmic protein,Huntingtin, SODIUM ION, ZINC ION
著者Kim, M.
登録日2012-05-29
公開日2013-03-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues.
Prion, 7, 2013
5JJ4
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BU of 5jj4 by Molmil
Crystal Structure of a Variant Human Activation-induced Deoxycytidine Deaminase as an MBP fusion protein
分子名称: CALCIUM ION, Maltose-binding periplasmic protein,Single-stranded DNA cytosine deaminase, ZINC ION, ...
著者Pedersen, L.C, Goodman, M.F, Pham, P, Afif, S.A.
登録日2016-04-22
公開日2016-06-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.807 Å)
主引用文献Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification.
DNA Repair (Amst.), 43, 2016
4FED
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BU of 4fed by Molmil
Crystal Structure of Htt36Q3H
分子名称: CALCIUM ION, Maltose-binding periplasmic protein,Huntingtin, ZINC ION
著者Kim, M.
登録日2012-05-30
公開日2013-03-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.807 Å)
主引用文献Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues.
Prion, 7, 2013
6EG3
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BU of 6eg3 by Molmil
Crystal structure of human BRM in complex with compound 15
分子名称: 3-[(4-{[(2-chloropyridin-4-yl)carbamoyl]amino}pyridin-2-yl)ethynyl]benzoic acid, ETHANOL, Maltose/maltodextrin-binding periplasmic protein,Probable global transcription activator SNF2L2
著者Zhu, X, Kulathila, R, Hu, T, Xie, X.
登録日2018-08-17
公開日2018-10-31
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.
J. Med. Chem., 61, 2018
6DD5
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BU of 6dd5 by Molmil
Crystal Structure of the Cas6 Domain of Marinomonas mediterranea MMB-1 Cas6-RT-Cas1 Fusion Protein
分子名称: GLYCEROL, MMB-1 Cas6 Fused to Maltose Binding Protein,CRISPR-associated endonuclease Cas1, SULFATE ION, ...
著者Stamos, J.L, Mohr, G, Silas, S, Makarova, K.S, Markham, L.M, Yao, J, Lucas-Elio, P, Sanchez-Amat, A, Fire, A.Z, Koonin, E.V, Lambowitz, A.M.
登録日2018-05-09
公開日2018-10-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献A Reverse Transcriptase-Cas1 Fusion Protein Contains a Cas6 Domain Required for Both CRISPR RNA Biogenesis and RNA Spacer Acquisition.
Mol. Cell, 72, 2018
5W0U
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BU of 5w0u by Molmil
Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with dCMP
分子名称: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*TP*GP*GP*CP*CP*TP*TP*GP*AP*AP*C)-3'), ...
著者Qiao, Q, Wang, L, Wu, H.
登録日2017-05-31
公開日2017-08-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献AID Recognizes Structured DNA for Class Switch Recombination.
Mol. Cell, 67, 2017
6EG2
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BU of 6eg2 by Molmil
Crystal structure of human BRM in complex with compound 16
分子名称: ISOPROPYL ALCOHOL, Maltose/maltodextrin-binding periplasmic protein,Probable global transcription activator SNF2L2, N-(5-amino-2-chloropyridin-4-yl)-N'-(4-bromo-3-{[3-(hydroxymethyl)phenyl]ethynyl}-1,2-thiazol-5-yl)urea
著者Zhu, X, Kulathila, R, Hu, T, Xie, X.
登録日2018-08-17
公開日2018-10-31
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.98 Å)
主引用文献Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.
J. Med. Chem., 61, 2018
5LEM
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BU of 5lem by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_11_3G124 in complex with Maltose-binding Protein and Green Fluorescent Protein
分子名称: DD_Off7_11_3G124, Green fluorescent protein, Maltose-binding periplasmic protein
著者Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A.
登録日2016-06-30
公開日2017-08-02
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (2.98 Å)
主引用文献Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
4FE8
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BU of 4fe8 by Molmil
Crystal Structure of Htt36Q3H-EX1-X1-C1(Alpha)
分子名称: Maltose-binding periplasmic protein,Huntingtin, ZINC ION
著者Kim, M.
登録日2012-05-29
公開日2013-03-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues.
Prion, 7, 2013
4FEC
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BU of 4fec by Molmil
Crystal Structure of Htt36Q3H
分子名称: Maltose-binding periplasmic protein,Huntingtin, ZINC ION
著者Kim, M.
登録日2012-05-30
公開日2013-03-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues.
Prion, 7, 2013
5LEL
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BU of 5lel by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_10_3G124 in complex with Maltose-binding Protein and Green Fluorescent Protein
分子名称: DD_Off7_10_3G124, Green fluorescent protein, Maltose-binding periplasmic protein
著者Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A.
登録日2016-06-30
公開日2017-11-15
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017

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