8VLX

HTT in complex with HAP40 and a small molecule.

This is a non-PDB format compatible entry.

Summary for 8VLX

• Entry DOI: 10.2210/pdb8vlx/pdb
• EMDB information: 43347
• Descriptor: Huntingtin, 40-kDa huntingtin-associated protein, N-[(1S,2R)-2-benzylcyclopentyl]-N'-{1-[(1S)-1-(pyridin-4-yl)ethyl]piperidin-4-yl}urea (3 entities in total)
• Functional Keywords: huntington's disease, neurodegenerative disease, unknown function
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 395242.47

Authors

Poweleit, N.,Boudet, J.,Doherty, E. (deposition date: 2024-01-12, release date: 2024-03-06, Last modification date: 2024-10-16)

• Primary citation: Poweleit, N.,Boudet, J.,Doherty, E.; Discovery of a Small Molecule Ligand to the Huntingtin/HAP40 complex; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.6 Å)