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8VLX

HTT in complex with HAP40 and a small molecule.

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Huntingtinpolymer3187353493.71UniProt (P42858)
Pfam (PF20926)
Pfam (PF20925)
Pfam (PF20927)
Homo sapiens (human)Huntington disease protein,HD protein
2B
(B)
40-kDa huntingtin-associated proteinpolymer38941342.31UniProt (P23610)Homo sapiens (human)HAP40,CpG island protein,Factor VIII intron 22 protein
3C
(B)
N-[(1S,2R)-2-benzylcyclopentyl]-N'-{1-[(1S)-1-(pyridin-4-yl)ethyl]piperidin-4-yl}ureanon-polymer406.61Chemie (A1ACS)
Sequence modifications
A: 1 - 3169 (UniProt: P42858)
PDBExternal DatabaseDetails
Gln 23-insertion
Gln 24-insertion
Gln 25-insertion
Gln 26-insertion
Gln 27-insertion
Gln 28-insertion
Gln 29-insertion
Gln 30-insertion
Gln 31-insertion
Gln 32-insertion
Gln 33-insertion
Gln 34-insertion
Gln 35-insertion
Gln 36-insertion
Gln 37-insertion
Gln 38-insertion
Gln 39-insertion
Gln 40-insertion
Gln 41-insertion
Gln 42-insertion
Gln 43-insertion
Gln 44-insertion
Gln 45-insertion
Gln 46-insertion
Gln 47-insertion
Gln 48-insertion
Gln 49-insertion
Ala 3170-expression tag
Ala 3171-expression tag
Ala 3172-expression tag
Glu 3173-expression tag
Asn 3174-expression tag
Leu 3175-expression tag
Tyr 3176-expression tag
Phe 3177-expression tag
Gln 3178-expression tag
Gly 3179-expression tag
Asp 3180-expression tag
Tyr 3181-expression tag
Lys 3182-expression tag
Asp 3183-expression tag
Asp 3184-expression tag
Asp 3185-expression tag
Asp 3186-expression tag
Lys 3187-expression tag
B: 19 - 389 (UniProt: P23610)
PDBExternal DatabaseDetails
Met 1-expression tag
His 2-expression tag
His 3-expression tag
His 4-expression tag
His 5-expression tag
His 6-expression tag
His 7-expression tag
Ser 8-expression tag
Ser 9-expression tag
Gly 10-expression tag
Arg 11-expression tag
Glu 12-expression tag
Asn 13-expression tag
Leu 14-expression tag
Tyr 15-expression tag
Phe 16-expression tag
Gln 17-expression tag
Gly 18-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight394835.9
Non-Polymers*Number of molecules1
Total formula weight406.6
All*Total formula weight395242.5
*Water molecules are not included.

227561

PDB entries from 2024-11-20

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