5V6Y
Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and altered selectivity adrenomedullin variant
Summary for 5V6Y
Entry DOI | 10.2210/pdb5v6y/pdb |
Related | 4RWG |
Related PRD ID | PRD_900001 |
Descriptor | Maltose-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor, ADM, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | class b g protein-coupled receptor, gpcr, calcitonin family peptide, transport protein - membrane protein complex, transport protein / membrane protein |
Biological source | Escherichia coli O157:H7 More |
Total number of polymer chains | 8 |
Total formula weight | 274192.04 |
Authors | Pioszak, A.,Booe, J. (deposition date: 2017-03-17, release date: 2018-01-31, Last modification date: 2023-10-04) |
Primary citation | Booe, J.M.,Warner, M.L.,Roehrkasse, A.M.,Hay, D.L.,Pioszak, A.A. Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists. Mol. Pharmacol., 93:355-367, 2018 Cited by PubMed: 29363552DOI: 10.1124/mol.117.110916 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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