5V6Y

Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and altered selectivity adrenomedullin variant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0006886	biological_process	intracellular protein transport
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
A	0008643	biological_process	carbohydrate transport
A	0015026	molecular_function	coreceptor activity
A	0015144	molecular_function	carbohydrate transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0004930	molecular_function	G protein-coupled receptor activity
B	0006886	biological_process	intracellular protein transport
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
B	0008643	biological_process	carbohydrate transport
B	0015026	molecular_function	coreceptor activity
B	0015144	molecular_function	carbohydrate transmembrane transporter activity
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0004930	molecular_function	G protein-coupled receptor activity
C	0006886	biological_process	intracellular protein transport
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
C	0008643	biological_process	carbohydrate transport
C	0015026	molecular_function	coreceptor activity
C	0015144	molecular_function	carbohydrate transmembrane transporter activity
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0004930	molecular_function	G protein-coupled receptor activity
D	0006886	biological_process	intracellular protein transport
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
D	0008643	biological_process	carbohydrate transport
D	0015026	molecular_function	coreceptor activity
D	0015144	molecular_function	carbohydrate transmembrane transporter activity
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00649
Number of Residues	25
Details	G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtWDgwl.CWndVaagtesmqlCP

Chain	Residue	Details
A	CYS2065-PRO2089

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site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
A	PRO109-ASN126

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Tyrosine amide => ECO:0000269|PubMed:8387282

Chain	Residue	Details
E	PHE52
F	PHE52
G	PHE52
H	PHE52
B	ASN2118
B	ASN2123
C	ASN2066
C	ASN2118
C	ASN2123
D	ASN2066
D	ASN2118
D	ASN2123

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