5V6Y
Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and altered selectivity adrenomedullin variant
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Maltose-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor | polymer | 593 | 66304.6 | 4 | UniProt (P0AEY0) UniProt (O60894) UniProt (Q16602) Pfam (PF01547) Pfam (PF04901) Pfam (PF02793) UniProt (by SIFTS) (P0AEX9) In PDB | Escherichia coli O157:H7 | MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Calcitonin-receptor-like receptor activity-modifying protein 1,CRLR activity-modifying protein 1,CGRP type 1 receptor,Calcitonin receptor-like receptor |
2 | E, F, G, H | ADM | polymer | 17 | 1901.2 | 4 | UniProt (P35318) In PDB | Homo sapiens | |
3 | I, J, K, L | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 4 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | alpha-maltose | ||
4 | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 368 (UniProt: P0AEY0)
A, B, C, D: 1024 - 2019 (UniProt: O60894)
A, B, C, D: 2029 - 2144 (UniProt: Q16602)
E, F, G, H: 37 - 52 (UniProt: P35318)
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Asn 369 | - | linker |
Ala 370 | - | linker |
Ala 371 | - | linker |
Ala 372 | - | linker |
Glu 373 | - | linker |
Phe 374 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 2020 | - | linker |
Ser 2021 | - | linker |
Ala 2022 | - | linker |
Gly 2023 | - | linker |
Ser 2024 | - | linker |
Ala 2025 | - | linker |
Gly 2026 | - | linker |
Ser 2027 | - | linker |
Ala 2028 | - | linker |
PDB | External Database | Details |
---|---|---|
His 2145 | - | expression tag |
His 2146 | - | expression tag |
His 2147 | - | expression tag |
His 2148 | - | expression tag |
His 2149 | - | expression tag |
His 2150 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Trp 45 | Ser 139 | engineered mutation |
Leu 46 | Lys 140 | engineered mutation |
Trp 50 | Gln 144 | engineered mutation |
Phe 52 | Tyr 146 | engineered mutation |
Nh2 53 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 272822.9 | |
Branched | Number of molecules | 4 |
Total formula weight | 1369.2 | |
All* | Total formula weight | 274192.0 |