2INQ
 
 | | Neutron Crystal Structure of Escherichia coli Dihydrofolate Reductase Bound to the Anti-cancer drug, Methotrexate | | 分子名称: | Dihydrofolate reductase, N-(4-{[(2,4-DIAMINOPTERIDIN-1-IUM-6-YL)METHYL](METHYL)AMINO}BENZOYL)-L-GLUTAMIC ACID | | 著者 | Bennett, B.C, Langan, P.A, Coates, L, Schoenborn, B, Dealwis, C.G. | | 登録日 | 2006-10-08 | | 公開日 | 2007-02-06 | | 最終更新日 | 2023-08-30 | | 実験手法 | NEUTRON DIFFRACTION (2.2 Å) | | 主引用文献 | Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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1RX3
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1DDS
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1RX4
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4EIZ
 | | Structure of Nb113 bound to apoDHFR | | 分子名称: | Dihydrofolate reductase, Nb113 Camel antibody fragment | | 著者 | Oyen, D, Srinivasan, V. | | 登録日 | 2012-04-06 | | 公開日 | 2013-04-24 | | 最終更新日 | 2013-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
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6CQA
 | | E. coli DHFR complex with inhibitor AMPQD | | 分子名称: | 7-[(3-aminophenyl)methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine, Dihydrofolate reductase, SULFATE ION | | 著者 | Cao, H, Rodrigues, J, Benach, J, Wasserman, S, Morisco, L, Koss, J, Shakhnovich, E, Skolnick, J. | | 登録日 | 2018-03-14 | | 公開日 | 2019-01-09 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release.
Commun Biol, 1, 2018
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5Z6M
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5DFR
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1RX5
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1DRH
 | | ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS | | 分子名称: | DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Sawaya, M.R, Kraut, J. | | 登録日 | 1994-11-30 | | 公開日 | 1995-02-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Biochemistry, 34, 1995
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1RX7
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1RB3
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7NAE
 | | Crystal structure of Escherichia coli dihydrofolate reductase in complex with TRIMETHOPRIM | | 分子名称: | Dihydrofolate reductase, SULFATE ION, TRIMETHOPRIM | | 著者 | Estrada, A, Wright, D, Krucinska, J, Erlandsen, H. | | 登録日 | 2021-06-21 | | 公開日 | 2022-06-29 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.
Commun Biol, 5, 2022
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6DFR
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1RH3
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1DDR
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4EIG
 | | CA1698 camel antibody fragment in complex with DHFR | | 分子名称: | CA1698 camel antibody fragment, Dihydrofolate reductase | | 著者 | Oyen, D, Srinivasan, V. | | 登録日 | 2012-04-05 | | 公開日 | 2013-04-24 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
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7DFR
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1TDR
 | | EXPRESSION, CHARACTERIZATION, AND CRYSTALLOGRAPHIC ANALYSIS OF TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE | | 分子名称: | CALCIUM ION, CHLORIDE ION, METHOTREXATE, ... | | 著者 | Lewinski, K, Lebioda, L. | | 登録日 | 1995-04-13 | | 公開日 | 1995-07-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Expression, characterization and crystallographic analysis of telluromethionyl dihydrofolate reductase.
Acta Crystallogr.,Sect.D, 51, 1995
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1RE7
 | | DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE | | 分子名称: | DIHYDROFOLATE REDUCTASE, FOLIC ACID | | 著者 | Sawaya, M.R. | | 登録日 | 1996-11-01 | | 公開日 | 1996-12-23 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
Biochemistry, 36, 1997
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1DRE
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1RD7
 | | DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE | | 分子名称: | BETA-MERCAPTOETHANOL, DIHYDROFOLATE REDUCTASE, FOLIC ACID | | 著者 | Sawaya, M.R, Kraut, J. | | 登録日 | 1996-11-01 | | 公開日 | 1996-12-23 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
Biochemistry, 36, 1997
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2ANO
 | | Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17 | | 分子名称: | 1-{[N-(1-IMINO-GUANIDINO-METHYL)]SULFANYLMETHYL}-3-TRIFLUOROMETHYL-BENZENE, Dihydrofolate reductase, MANGANESE (II) ION, ... | | 著者 | Summerfield, R.L, Daigle, D.M, Mayer, S, Jackson, S.G, Organ, M, Hughes, D.W, Brown, E.D, Junop, M.S. | | 登録日 | 2005-08-11 | | 公開日 | 2006-07-25 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | A 2.13 A Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region
J.Med.Chem., 49, 2006
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4FHB
 | | Enhancing DHFR catalysis by binding of an allosteric regulator nanobody (Nb179) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Oyen, D. | | 登録日 | 2012-06-06 | | 公開日 | 2013-04-24 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
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1RX8
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