7NAE

Crystal structure of Escherichia coli dihydrofolate reductase in complex with TRIMETHOPRIM

Summary for 7NAE

Entry DOI	10.2210/pdb7nae/pdb
Descriptor	Dihydrofolate reductase, TRIMETHOPRIM, SULFATE ION, ... (4 entities in total)
Functional Keywords	dihydrofolate reductase, oxidoreductase
Biological source	Escherichia coli (strain K12)
Total number of polymer chains	1
Total formula weight	20137.42
Authors	Estrada, A.,Wright, D.,Krucinska, J.,Erlandsen, H. (deposition date: 2021-06-21, release date: 2022-06-29, Last modification date: 2023-10-18)
Primary citation	Krucinska, J.,Lombardo, M.N.,Erlandsen, H.,Estrada, A.,Si, D.,Viswanathan, K.,Wright, D.L. Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens. Commun Biol, 5:459-459, 2022 Cited by PubMed: 35562546 DOI: 10.1038/s42003-022-03384-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation