7NAE

Crystal structure of Escherichia coli dihydrofolate reductase in complex with TRIMETHOPRIM

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Dihydrofolate reductase	polymer	169	19366.8	1	UniProt (P0ABQ4) Pfam (PF00186) In PDB	Escherichia coli (strain K12)
2	A	TRIMETHOPRIM	non-polymer		290.3	1	Chemie (TOP)
3	A	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
4		water	water		18.0	35	Chemie (HOH)

Sequence modifications

A: 1 - 159 (UniProt: P0ABQ4)

PDB	External Database	Details
Leu 160	-	expression tag
Glu 161	-	expression tag
His 162	-	expression tag
His 163	-	expression tag
His 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
His 167	-	expression tag
His 168	-	expression tag
His 169	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	19366.8
Non-Polymers*	Number of molecules	6
	Total formula weight	770.6
All*	Total formula weight	20137.4

*Water molecules are not included.