7NAE
Crystal structure of Escherichia coli dihydrofolate reductase in complex with TRIMETHOPRIM
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydrofolate reductase | polymer | 169 | 19366.8 | 1 | UniProt (P0ABQ4) Pfam (PF00186) | Escherichia coli (strain K12) | |
| 2 | B (A) | TRIMETHOPRIM | non-polymer | 290.3 | 1 | Chemie (TOP) | |||
| 3 | C, D, E, F, G (A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | H (A) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A: 1 - 159 (UniProt: P0ABQ4)
| PDB | External Database | Details |
|---|---|---|
| Leu 160 | - | expression tag |
| Glu 161 | - | expression tag |
| His 162 | - | expression tag |
| His 163 | - | expression tag |
| His 164 | - | expression tag |
| His 165 | - | expression tag |
| His 166 | - | expression tag |
| His 167 | - | expression tag |
| His 168 | - | expression tag |
| His 169 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19366.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 770.6 | |
| All* | Total formula weight | 20137.4 |
