2INQ

Neutron Crystal Structure of Escherichia coli Dihydrofolate Reductase Bound to the Anti-cancer drug, Methotrexate

Summary for 2INQ

Entry DOI	10.2210/pdb2inq/pdb
Descriptor	Dihydrofolate reductase, N-(4-{[(2,4-DIAMINOPTERIDIN-1-IUM-6-YL)METHYL](METHYL)AMINO}BENZOYL)-L-GLUTAMIC ACID (3 entities in total)
Functional Keywords	neutron structure; deuterium exchange; pseudo-rossman fold; nucleotide binding domain; chemotherapy, oxidoreductase
Biological source	Escherichia coli K12
Total number of polymer chains	2
Total formula weight	36951.55
Authors	Bennett, B.C.,Langan, P.A.,Coates, L.,Schoenborn, B.,Dealwis, C.G. (deposition date: 2006-10-08, release date: 2007-02-06, Last modification date: 2023-08-30)
Primary citation	Bennett, B.C.,Langan, P.A.,Coates, L.,Mustyakimov, M.,Schoenborn, B.,Howell, E.E.,Dealwis, C.G. Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate. Proc.Natl.Acad.Sci.Usa, 103:18493-18498, 2006 Cited by PubMed: 17130456 DOI: 10.1073/pnas.0604977103 PDB entries with the same primary citation
Experimental method	NEUTRON DIFFRACTION (2.2 Å)

Structure validation