1RX4

DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH 5,10-DIDEAZATETRAHYDROFOLATE AND 2'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE

Summary for 1RX4

Entry DOI	10.2210/pdb1rx4/pdb
Descriptor	DIHYDROFOLATE REDUCTASE, 5,10-DIDEAZATETRAHYDROFOLIC ACID, BETA-MERCAPTOETHANOL, ... (5 entities in total)
Functional Keywords	oxido-reductase nadp, trimethoprim resistance, methotrexate resistance, one-carbon metabolism, oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	19285.32
Authors	Sawaya, M.R. (deposition date: 1996-09-19, release date: 1997-01-11, Last modification date: 2024-04-03)
Primary citation	Sawaya, M.R.,Kraut, J. Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36:586-603, 1997 Cited by PubMed: 9012674 DOI: 10.1021/bi962337c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation