5DFR

CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING

Summary for 5DFR

DescriptorDIHYDROFOLATE REDUCTASE, CHLORIDE ION (3 entities in total)
Functional Keywordsoxido-reductase, oxidoreductase
Biological sourceEscherichia coli
Total number of polymer chains1
Total molecular weight18126.69
Authors
Bystroff, C.,Kraut, J. (deposition date: 1988-10-21, release date: 1990-07-15, Last modification date: 2017-11-29)
Primary citation
Bystroff, C.,Kraut, J.
Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding.
Biochemistry, 30:2227-2239, 1991
PubMed: 1998681 (PDB entries with the same primary citation)
DOI: 10.1021/bi00222a028
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers370 18.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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171313
PDB entries from 2020-11-18