5DFR

CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	DIHYDROFOLATE REDUCTASE	polymer	159	18020.3	1	UniProt (P0ABQ4) Pfam (PF00186) In PDB	Escherichia coli
2	A	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
3		water	water		18.0	120	Chemie (HOH)

Sequence modifications

A: 1 - 159 (UniProt: P0ABQ4)

PDB	External Database	Details
Asp 37	Asn 37	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	18020.3
Non-Polymers*	Number of molecules	3
	Total formula weight	106.4
All*	Total formula weight	18126.7

*Water molecules are not included.