3U9W
| Structure of human Leukotriene A4 hydrolase in complex with inhibitor sc57461A | 分子名称: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | 著者 | Niegowski, D, Thunnissen, M, Tholander, F, Rinaldo-Matthis, A, Muroya, A, Haeggstrom, J.Z. | 登録日 | 2011-10-20 | 公開日 | 2012-10-24 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Structure of human Leukotriene A4 hydrolase in complex with inhibitor sc57461A To be Published
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8AVA
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8AWH
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3B7S
| [E296Q]LTA4H in complex with RSR substrate | 分子名称: | ACETIC ACID, GLYCEROL, Leukotriene A-4 hydrolase, ... | 著者 | Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C. | 登録日 | 2007-10-31 | 公開日 | 2008-09-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.465 Å) | 主引用文献 | Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design. Chem.Biol., 15, 2008
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5NI2
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5NI6
| Crystal structure of human LTA4H mutant D375N in complex with LTA4 | 分子名称: | 5S-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid, ACETIC ACID, Leukotriene A-4 hydrolase, ... | 著者 | Stsiapanava, A. | 登録日 | 2017-03-23 | 公開日 | 2017-08-23 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Capturing LTA4 hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4 synthesis. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5NID
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3FUN
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8QQ4
| LTA4 hydrolase in complex with compound 6(R) | 分子名称: | (2R)-2-azanyl-3-[5-[4-(5-chloranyl-3-fluoranyl-pyridin-2-yl)oxyphenyl]-1,2,3,4-tetrazol-2-yl]propan-1-ol, ACETATE ION, IMIDAZOLE, ... | 著者 | Srinivas, H. | 登録日 | 2023-10-03 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase. J.Med.Chem., 66, 2023
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4MKT
| Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue and 4-(4-benzylphenyl)thiazol-2-amine | 分子名称: | 1-{4-oxo-4-[(2S)-pyrrolidin-2-yl]butanoyl}-L-proline, 4-(4-benzylphenyl)-1,3-thiazol-2-amine, ACETIC ACID, ... | 著者 | Stsiapanava, A, Rinaldo-Matthis, A, Haeggstrom, J.Z. | 登録日 | 2013-09-05 | 公開日 | 2014-03-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.618 Å) | 主引用文献 | Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. Proc.Natl.Acad.Sci.USA, 111, 2014
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3FH5
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4L2L
| Human Leukotriene A4 Hydrolase complexed with ligand 4-(4-benzylphenyl)thiazol-2-amine | 分子名称: | 4-(4-benzylphenyl)-1,3-thiazol-2-amine, ACETATE ION, Leukotriene A-4 hydrolase, ... | 著者 | Stsiapanava, A, Rinaldo-Matthis, A, Haeggstrom, J.Z. | 登録日 | 2013-06-04 | 公開日 | 2014-03-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.648 Å) | 主引用文献 | Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. Proc.Natl.Acad.Sci.USA, 111, 2014
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4R7L
| Structure of Human Leukotriene A4 Hydrolase in complex with inhibitor H1 | 分子名称: | ACETATE ION, GLYCEROL, IMIDAZOLE, ... | 著者 | Ouyang, P, Cui, K, Lu, W, Huang, J. | 登録日 | 2014-08-27 | 公開日 | 2015-11-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Human Leukotriene A4 Hydrolase in complex with SAHA To be Published
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3FH8
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3FTV
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4MS6
| Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue | 分子名称: | 1-{4-oxo-4-[(2S)-pyrrolidin-2-yl]butanoyl}-L-proline, ACETIC ACID, Leukotriene A-4 hydrolase, ... | 著者 | Stsiapanava, A, Rinaldo-Matthis, A, Haeggstrom, J.Z. | 登録日 | 2013-09-18 | 公開日 | 2014-03-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. Proc.Natl.Acad.Sci.USA, 111, 2014
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5NIA
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7AV1
| LTA4 hydrolase in complex with fragment2 | 分子名称: | 2-[5-(4-methoxyphenyl)-1,2,3,4-tetrazol-2-yl]ethanamine, ACETATE ION, IMIDAZOLE, ... | 著者 | Srinivas, H. | 登録日 | 2020-11-03 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase. J.Med.Chem., 64, 2021
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2VJ8
| Complex of human leukotriene A4 hydrolase with a hydroxamic acid inhibitor | 分子名称: | 6-[{(2S)-2-AMINO-3-[4-(BENZYLOXY)PHENYL]PROPYL}(HYDROXY)AMINO]-6-OXOHEXANOIC ACID), ACETATE ION, IMIDAZOLE, ... | 著者 | Thunnissen, M.M.G.M, Andersson, B, Wong, C.-H, Samuelsson, B, Haeggstrom, J.Z. | 登録日 | 2007-12-07 | 公開日 | 2008-01-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal Structures of Leukotriene A4 Hydrolase in Complex with Captopril and Two Competitive Tight-Binding Inhibitors Faseb J., 16, 2002
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3CHO
| Crystal structure of leukotriene a4 hydrolase in complex with 2-amino-N-[4-(phenylmethoxy)phenyl]-acetamide | 分子名称: | ACETATE ION, Leukotriene A-4 hydrolase, N-[4-(benzyloxy)phenyl]glycinamide, ... | 著者 | Thunnissen, M.M.G.M, Adler, M, Whitlow, M. | 登録日 | 2008-03-10 | 公開日 | 2008-04-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg.Med.Chem., 16, 2008
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3FU0
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3FUH
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3B7R
| Leukotriene A4 Hydrolase Complexed with Inhibitor RB3040 | 分子名称: | IMIDAZOLE, Leukotriene A-4 hydrolase, N-[3-[(1-AMINOETHYL)(HYDROXY)PHOSPHORYL]-2-(1,1'-BIPHENYL-4-YLMETHYL)PROPANOYL]ALANINE, ... | 著者 | Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C. | 登録日 | 2007-10-31 | 公開日 | 2008-09-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.811 Å) | 主引用文献 | Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design. Chem.Biol., 15, 2008
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6ENB
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8RX7
| LTA4 hydrolase in complex with compound2 | 分子名称: | 5-(4-phenoxyphenyl)-1~{H}-imidazole, ACETATE ION, IMIDAZOLE, ... | 著者 | Srinivas, H. | 登録日 | 2024-02-06 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor. J.Med.Chem., 67, 2024
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