7AV1

LTA4 hydrolase in complex with fragment2

Summary for 7AV1

Entry DOI	10.2210/pdb7av1/pdb
Descriptor	Leukotriene A-4 hydrolase, ZINC ION, ACETATE ION, ... (7 entities in total)
Functional Keywords	inhibitor, complex, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	70271.94
Authors	Srinivas, H. (deposition date: 2020-11-03, release date: 2021-02-17, Last modification date: 2024-01-31)
Primary citation	Markert, C.,Thoma, G.,Srinivas, H.,Bollbuck, B.,Luond, R.M.,Miltz, W.,Walchli, R.,Wolf, R.,Hinrichs, J.,Bergsdorf, C.,Azzaoui, K.,Penno, C.A.,Klein, K.,Wack, N.,Jager, P.,Hasler, F.,Beerli, C.,Loetscher, P.,Dawson, J.,Wieczorek, G.,Numao, S.,Littlewood-Evans, A.,Rohn, T.A. Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase. J.Med.Chem., 64:1889-1903, 2021 Cited by PubMed: 33592148 DOI: 10.1021/acs.jmedchem.0c01955 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation