6ENB

LTA4 hydrolase (E297Q) mutant in complex with Pro-Gly-Pro peptide

Summary for 6ENB

• Entry DOI: 10.2210/pdb6enb/pdb
• Descriptor: Leukotriene A-4 hydrolase, PRO-GLY-PRO, ZINC ION, ... (7 entities in total)
• Functional Keywords: lta4h, substrate, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 70097.76

Authors

Srinivas, H. (deposition date: 2017-10-04, release date: 2017-12-13, Last modification date: 2019-10-16)

• Primary citation: Numao, S.,Hasler, F.,Laguerre, C.,Srinivas, H.,Wack, N.,Jager, P.,Schmid, A.,Osmont, A.,Rothlisberger, P.,Houguenade, J.,Bergsdorf, C.,Dawson, J.,Carte, N.,Hofmann, A.,Markert, C.,Hardaker, L.,Billich, A.,Wolf, R.M.,Penno, C.A.,Bollbuck, B.,Miltz, W.,Rohn, T.A.; Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors.; Sci Rep, 7:13591-13591, 2017; PubMed: 29051536; DOI: 10.1038/s41598-017-13490-1

Experimental method

X-RAY DIFFRACTION (1.84 Å)