6I44
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6i44 by Molmil](/molmil-images/mine/6i44) | Allosteric activation of human prekallikrein by apple domain disc rotation | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... | 著者 | Li, C, Pathak, M, MaCrae, K, Dreveny, I, Emsley, J. | 登録日 | 2018-11-09 | 公開日 | 2019-03-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI. J.Thromb.Haemost., 17, 2019
|
|
2ANY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2any by Molmil](/molmil-images/mine/2any) | Expression, Crystallization and the Three-dimensional Structure of the Catalytic Domain of Human Plasma Kallikrein: Implications for Structure-Based Design of Protease Inhibitors | 分子名称: | BENZAMIDINE, PHOSPHATE ION, plasma kallikrein, ... | 著者 | Tang, J, Yu, C.L, Williams, S.R, Springman, E, Jeffery, D, Sprengeler, P.A, Estevez, A, Sampang, J, Shrader, W, Spencer, J.R, Young, W.B, McGrath, M.E, Katz, B.A. | 登録日 | 2005-08-11 | 公開日 | 2005-10-11 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein. J.Biol.Chem., 280, 2005
|
|
5TJX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5tjx by Molmil](/molmil-images/mine/5tjx) | Structure of human plasma kallikrein | 分子名称: | (8E)-3-amino-1-methyl-15-[(1H-pyrazol-1-yl)methyl]-7,10,11,12,24,25-hexahydro-6H,18H,23H-19,22-(metheno)pyrido[4,3-j][1,9,13,17,18]benzodioxatriazacyclohenicosin-23-one, PHOSPHATE ION, Plasma kallikrein | 著者 | Partridge, J.R, Choy, R.M, Li, Z. | 登録日 | 2016-10-05 | 公開日 | 2016-12-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.408 Å) | 主引用文献 | Structure-Guided Design of Novel, Potent, and Selective Macrocyclic Plasma Kallikrein Inhibitors. ACS Med Chem Lett, 8, 2017
|
|
6T7P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6t7p by Molmil](/molmil-images/mine/6t7p) | human plasmakallikrein protease domain in complex with active site directed inhibitor | 分子名称: | (2~{S},4~{R})-1-[[(3~{S})-3-azanyl-2,3-dihydro-1-benzofuran-6-yl]carbonyl]-~{N}-(3-chlorophenyl)-4-phenyl-pyrrolidine-2-carboxamide, DIMETHYL SULFOXIDE, GLUTATHIONE, ... | 著者 | Renatus, M. | 登録日 | 2019-10-22 | 公開日 | 2020-07-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.416 Å) | 主引用文献 | Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach. J.Med.Chem., 63, 2020
|
|
5F8Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5f8z by Molmil](/molmil-images/mine/5f8z) | The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-1 | 分子名称: | CYS-PRO-ALA-ARG-PHE-M70-ALA-LEU-PHE-CYS, Plasma kallikrein LIGHT CHAIN, SULFATE ION, ... | 著者 | Xu, M, Jiang, L, Xu, P, Luo, Z, Andreasen, P, Huang, M. | 登録日 | 2015-12-09 | 公開日 | 2016-12-14 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-1 To Be Published
|
|
5F8X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5f8x by Molmil](/molmil-images/mine/5f8x) | The crystal structure of human plasma kallikrein in complex with its peptide inhibitor pkalin-3 | 分子名称: | CYS-PRO-ALA-ARG-PHE-M70-ALA-LEU-TRP-CYS, Plasma kallikrein, SULFATE ION, ... | 著者 | Xu, M, Jiang, L, Xu, P, Luo, Z, Andreasen, P, Huang, M. | 登録日 | 2015-12-09 | 公開日 | 2016-12-14 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | The Crystal Structure Of Human Plasma Kallikrein In Complex With Its Peptide Inhibitor Pkalin-3 To Be Published
|
|
6O1S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6o1s by Molmil](/molmil-images/mine/6o1s) | Structure of human plasma kallikrein protease domain with inhibitor | 分子名称: | 1,2-ETHANEDIOL, N-[(6-amino-2,4-dimethylpyridin-3-yl)methyl]-1-({4-[(1H-pyrazol-1-yl)methyl]phenyl}methyl)-1H-pyrazole-4-carboxamide, PHOSPHATE ION, ... | 著者 | Partridge, J.R, Choy, R.M. | 登録日 | 2019-02-21 | 公開日 | 2019-03-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition. J.Struct.Biol., 206, 2019
|
|
5F8T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5f8t by Molmil](/molmil-images/mine/5f8t) | The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2 | 分子名称: | CYS-PRO-LYS-ARG-PHE-M70-ALA-LEU-PHE-CYS, Plasma kallikrein light chain, SULFATE ION, ... | 著者 | Xu, M, Jiang, L, Xu, P, Luo, Z, Andreasen, P, Huang, M. | 登録日 | 2015-12-09 | 公開日 | 2016-12-14 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2 To Be Published
|
|
8A3Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8a3q by Molmil](/molmil-images/mine/8a3q) | Human Plasma Kallekrein in complex with 14W | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Plasma kallikrein, ... | 著者 | McEwan, P.A. | 登録日 | 2022-06-08 | 公開日 | 2022-11-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedema. J.Med.Chem., 65, 2022
|
|
2ANW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2anw by Molmil](/molmil-images/mine/2anw) | Expression, crystallization and three-dimensional structure of the catalytic domain of human plasma kallikrein: Implications for structure-based design of protease inhibitors | 分子名称: | BENZAMIDINE, plasma kallikrein, light chain | 著者 | Tang, J, Yu, C.L, Williams, S.R, Springman, E, Jeffery, D, Sprengeler, P.A, Estevez, A, Sampang, J, Shrader, W, Spencer, J.R, Young, W.B, McGrath, M.E, Katz, B.A. | 登録日 | 2005-08-11 | 公開日 | 2005-10-11 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein. J.Biol.Chem., 280, 2005
|
|
7N7X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7n7x by Molmil](/molmil-images/mine/7n7x) | Crystal structure of BCX7353(ORLADEYO) in complex with human plasma kallikrein serine protease domain at 2.1 angstrom resolution | 分子名称: | Orladeyo, PHOSPHATE ION, Plasma kallikrein light chain | 著者 | Krishnan, R, Yarlagadda, B.S, Kotian, P, Polach, K.J, Zhang, W. | 登録日 | 2021-06-11 | 公開日 | 2021-09-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.097 Å) | 主引用文献 | Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE). J.Med.Chem., 64, 2021
|
|
4OGY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ogy by Molmil](/molmil-images/mine/4ogy) | Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.1 Angstrom resolution | 分子名称: | 1,2-ETHANEDIOL, DX-2930 HEAVY CHAIN, DX-2930 LIGHT CHAIN, ... | 著者 | Edwards, T.E, Clifton, M.C, Abendroth, J, Nixon, A, Ladner, R. | 登録日 | 2014-01-16 | 公開日 | 2014-07-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Inhibition of plasma kallikrein by a highly specific active site blocking antibody. J.Biol.Chem., 289, 2014
|
|
6O1G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6o1g by Molmil](/molmil-images/mine/6o1g) | Full length human plasma kallikrein with inhibitor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(6-amino-2,4-dimethylpyridin-3-yl)methyl]-1-({4-[(1H-pyrazol-1-yl)methyl]phenyl}methyl)-1H-pyrazole-4-carboxamide, Plasma kallikrein | 著者 | Partridge, J.R, Choy, R.M. | 登録日 | 2019-02-19 | 公開日 | 2019-03-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition. J.Struct.Biol., 206, 2019
|
|
7QOX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qox by Molmil](/molmil-images/mine/7qox) | Factor XI and Plasma Kallikrein apple domain structures reveals different kininogen bound complexes | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... | 著者 | Li, C, Awital, B, Wong, S, Dreveny, I, Meijers, J, Emsley, J. | 登録日 | 2021-12-29 | 公開日 | 2023-01-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI. J Thromb Haemost, 17, 2019
|
|
4OGX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ogx by Molmil](/molmil-images/mine/4ogx) | Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.4 Angstrom resolution | 分子名称: | DX-2930 HEAVY CHAIN, DX-2930 LIGHT CHAIN, Plasma kallikrein, ... | 著者 | Edwards, T.E, Clifton, M.C, Abendroth, J, Nixon, A, Ladner, R. | 登録日 | 2014-01-16 | 公開日 | 2014-07-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Inhibition of plasma kallikrein by a highly specific active site blocking antibody. J.Biol.Chem., 289, 2014
|
|
8FGX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8fgx by Molmil](/molmil-images/mine/8fgx) | Cryo-EM structure of the STAR-0215 Fab in complex with active human plasma kallikrein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Plasma kallikrein light chain, STAR-0215 Heavy chain, ... | 著者 | Fuller, J.R, Biris, N, Bista, P. | 登録日 | 2022-12-13 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | 主引用文献 | STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema. J.Pharmacol.Exp.Ther., 387, 2023
|
|