8FGX

Cryo-EM structure of the STAR-0215 Fab in complex with active human plasma kallikrein

Summary for 8FGX

• Entry DOI: 10.2210/pdb8fgx/pdb
• EMDB information: 29077
• Descriptor: STAR-0215 Light chain, STAR-0215 Heavy chain, Plasma kallikrein light chain, ... (4 entities in total)
• Functional Keywords: plasma kallikrein, plasma prekallikrein, fletcher factor, hereditary angioedema, hae, kininogenin, c1-inh, bradykinin, hydrolase-immune system complex, hydrolase/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 117240.32

Authors

Fuller, J.R.,Biris, N.,Bista, P. (deposition date: 2022-12-13, release date: 2023-09-06, Last modification date: 2023-10-25)

• Primary citation: Bedian, V.,Biris, N.,Omer, C.,Chung, J.K.,Fuller, J.,Dagher, R.,Chandran, S.,Harwin, P.,Kiselak, T.,Violin, J.,Nichols, A.,Bista, P.; STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema.; J.Pharmacol.Exp.Ther., 387:214-225, 2023; PubMed: 37643795; DOI: 10.1124/jpet.123.001740

Experimental method

ELECTRON MICROSCOPY (2.62 Å)