8FGX
Cryo-EM structure of the STAR-0215 Fab in complex with active human plasma kallikrein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0002542 | biological_process | Factor XII activation |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006508 | biological_process | proteolysis |
| C | 0006954 | biological_process | inflammatory response |
| C | 0007596 | biological_process | blood coagulation |
| C | 0007599 | biological_process | hemostasis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0031638 | biological_process | zymogen activation |
| C | 0031639 | biological_process | plasminogen activation |
| C | 0042730 | biological_process | fibrinolysis |
| C | 0051919 | biological_process | positive regulation of fibrinolysis |
| C | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| C | LEU430-CYS435 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAckGDSGGPLV |
| Chain | Residue | Details |
| C | ASP572-VAL583 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| B | TYR202-HIS208 | |
| A | TYR192-HIS198 |
| site_id | PS00495 |
| Number of Residues | 84 |
| Details | APPLE Apple domain. CltqLyenafFrggDVasmytpnaqyCqmrCTfhprClLFsFlpassindmekrfgCfLKdSvtgtlpkvhrtgav.SGhSLkqC |
| Chain | Residue | Details |
| C | CYS21-CYS104 | |
| C | CYS111-CYS194 | |
| C | CYS201-CYS284 | |
| C | CYS292-CYS375 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3521732","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3521732","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
