8A3Q

Human Plasma Kallekrein in complex with 14W

Summary for 8A3Q

Entry DOI	10.2210/pdb8a3q/pdb
Descriptor	Plasma kallikrein, UNKNOWN LIGAND, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
Functional Keywords	inhibitor, complex, serine-like protease, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	29782.66
Authors	McEwan, P.A. (deposition date: 2022-06-08, release date: 2022-11-02, Last modification date: 2024-01-31)
Primary citation	Davie, R.L.,Edwards, H.J.,Evans, D.M.,Hodgson, S.T.,Stocks, M.J.,Smith, A.J.,Rushbrooke, L.J.,Pethen, S.J.,Roe, M.B.,Clark, D.E.,McEwan, P.A.,Hampton, S.L. Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedema. J.Med.Chem., 65:13629-13644, 2022 Cited by PubMed: 36251573 DOI: 10.1021/acs.jmedchem.2c00921 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.801 Å)

Structure validation