8A3Q
Human Plasma Kallekrein in complex with 14W
Summary for 8A3Q
Entry DOI | 10.2210/pdb8a3q/pdb |
Descriptor | Plasma kallikrein, UNKNOWN LIGAND, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, serine-like protease, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 29782.66 |
Authors | McEwan, P.A. (deposition date: 2022-06-08, release date: 2022-11-02, Last modification date: 2024-01-31) |
Primary citation | Davie, R.L.,Edwards, H.J.,Evans, D.M.,Hodgson, S.T.,Stocks, M.J.,Smith, A.J.,Rushbrooke, L.J.,Pethen, S.J.,Roe, M.B.,Clark, D.E.,McEwan, P.A.,Hampton, S.L. Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedema. J.Med.Chem., 65:13629-13644, 2022 Cited by PubMed: 36251573DOI: 10.1021/acs.jmedchem.2c00921 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.801 Å) |
Structure validation
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