4OGX

Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.4 Angstrom resolution

Summary for 4OGX

• Entry DOI: 10.2210/pdb4ogx/pdb
• Related: 2ANY 4OGY
• Descriptor: Plasma kallikrein, DX-2930 HEAVY CHAIN, DX-2930 LIGHT CHAIN, ... (5 entities in total)
• Functional Keywords: fab, antibody, kallikrein, blood, plasma, plasma kallikrein- mediated edema, acute hereditary angioedema, hae, hmwk, serpin c1-inhibitor, c1-inh, hereditary angioedema, haw, bradykinin, fletcher factor, kininogenin, serine protease, edema, hydrolase-antibody complex, hydrolase/antibody
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P03952
• Total number of polymer chains: 3
• Total formula weight: 75206.37

Authors

Edwards, T.E.,Clifton, M.C.,Abendroth, J.,Nixon, A.,Ladner, R. (deposition date: 2014-01-16, release date: 2014-07-09, Last modification date: 2023-09-20)

• Primary citation: Kenniston, J.A.,Faucette, R.R.,Martik, D.,Comeau, S.R.,Lindberg, A.P.,Kopacz, K.J.,Conley, G.P.,Chen, J.,Viswanathan, M.,Kastrapeli, N.,Cosic, J.,Mason, S.,DiLeo, M.,Abendroth, J.,Kuzmic, P.,Ladner, R.C.,Edwards, T.E.,TenHoor, C.,Adelman, B.A.,Nixon, A.E.,Sexton, D.J.; Inhibition of plasma kallikrein by a highly specific active site blocking antibody.; J.Biol.Chem., 289:23596-23608, 2014; PubMed: 24970892; DOI: 10.1074/jbc.M114.569061

Experimental method

X-RAY DIFFRACTION (2.4 Å)