4OGX
Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.4 Angstrom resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Plasma kallikrein | polymer | 241 | 27144.8 | 1 | UniProt (P03952) Pfam (PF00089) | Homo sapiens (human) | Fletcher factor, Kininogenin, Plasma prekallikrein, Plasma kallikrein heavy chain, Plasma kallikrein light chain |
| 2 | B (H) | DX-2930 HEAVY CHAIN | polymer | 225 | 24039.1 | 1 | Pfam (PF07686) Pfam (PF07654) UniProt (by SIFTS) (S6C4R2) | Homo sapiens (human) | |
| 3 | C (L) | DX-2930 LIGHT CHAIN | polymer | 213 | 23446.0 | 1 | Pfam (PF07686) Pfam (PF07654) UniProt (by SIFTS) (Q7Z3Y4) | Homo sapiens (human) | |
| 4 | D, E, F, G, H... (A) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 5 | J, K, L (A, H, L) | water | water | 18.0 | 270 | Chemie (HOH) |
Sequence modifications
A: 391 - 631 (UniProt: P03952)
| PDB | External Database | Details |
|---|---|---|
| Glu 396 | Asn 396 | engineered mutation |
| Glu 453 | Asn 453 | engineered mutation |
| Glu 494 | Asn 494 | engineered mutation |
| Ser 503 | Cys 503 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 74630.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 576.4 | |
| All* | Total formula weight | 75206.4 |
