4OGY
Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.1 Angstrom resolution
Summary for 4OGY
Entry DOI | 10.2210/pdb4ogy/pdb |
Related | 2ANY 4OGX |
Descriptor | Plasma kallikrein, DX-2930 HEAVY CHAIN, DX-2930 LIGHT CHAIN, ... (5 entities in total) |
Functional Keywords | fab, antibody, kallikrein, blood, plasma, plasma kallikrein- mediated edema, acute hereditary angioedema, hae, hmwk, serpin c1-inhibitor, c1-inh, hereditary angioedema, haw, bradykinin, fletcher factor, kininogenin, serine protease, edema, hydrolase-antibody complex, hydrolase/antibody |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P03952 |
Total number of polymer chains | 6 |
Total formula weight | 149446.19 |
Authors | Edwards, T.E.,Clifton, M.C.,Abendroth, J.,Nixon, A.,Ladner, R. (deposition date: 2014-01-16, release date: 2014-07-09, Last modification date: 2023-09-20) |
Primary citation | Kenniston, J.A.,Faucette, R.R.,Martik, D.,Comeau, S.R.,Lindberg, A.P.,Kopacz, K.J.,Conley, G.P.,Chen, J.,Viswanathan, M.,Kastrapeli, N.,Cosic, J.,Mason, S.,DiLeo, M.,Abendroth, J.,Kuzmic, P.,Ladner, R.C.,Edwards, T.E.,TenHoor, C.,Adelman, B.A.,Nixon, A.E.,Sexton, D.J. Inhibition of plasma kallikrein by a highly specific active site blocking antibody. J.Biol.Chem., 289:23596-23608, 2014 Cited by PubMed: 24970892DOI: 10.1074/jbc.M114.569061 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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