7TR0
| CaKip3[2-436] - AMP-PNP in complex with a microtubule | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein, ... | 著者 | Benoit, M.P.M.H, Asenjo, A.B, Hunter, B, Allingham, J, Sosa, H. | 登録日 | 2022-01-27 | 公開日 | 2022-07-20 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape. Nat Commun, 13, 2022
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7TQZ
| Apo CaKip3[2-482] in complex with a microtubule | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein, ... | 著者 | Benoit, M.P.M.H, Asenjo, A.B, Hunter, B, Allingham, J.S, Sosa, H. | 登録日 | 2022-01-27 | 公開日 | 2022-07-13 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape. Nat Commun, 13, 2022
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5YLJ
| Crystal structure of T2R-TTL-Millepachine complex | 分子名称: | (E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Yang, J.H, Chen, L.J. | 登録日 | 2017-10-17 | 公開日 | 2018-04-11 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin. J. Biol. Chem., 293, 2018
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6BRY
| Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 6a | 分子名称: | 1-(2-chlorofuro[3,2-d]pyrimidin-4-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Kumar, G, Wang, Y, Li, W, White, S.W. | 登録日 | 2017-12-01 | 公開日 | 2018-06-27 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy. J. Med. Chem., 61, 2018
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7CE8
| Crystal structure of T2R-TTL-Compound11 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | 登録日 | 2020-06-22 | 公開日 | 2021-06-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.725 Å) | 主引用文献 | Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond. J.Med.Chem., 65, 2022
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6KPP
| BNC105 in complex with tubulin | 分子名称: | (6-methoxy-2-methyl-7-oxidanyl-1-benzofuran-3-yl)-(3,4,5-trimethoxyphenyl)methanone, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wang, T, Wu, C, Pu, D. | 登録日 | 2019-08-15 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.74524117 Å) | 主引用文献 | Unraveling the molecular mechanism of BNC105, a phase II clinical trial vascular disrupting agent, provides insights into drug design. Biochem.Biophys.Res.Commun., 2020
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6LSM
| Tubulin Polymerization Inhibitors | 分子名称: | 2-(4-methylphenyl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Gang, L, Wang, Y.X, Chen, J.J. | 登録日 | 2020-01-17 | 公開日 | 2021-01-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.751 Å) | 主引用文献 | Design, Synthesis, and Bioevaluation of Pyrazolo[1,5-a]Pyrimidine Derivatives as Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site with Potent Anticancer Activities To Be Published
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8JJC
| Tubulin-Y62 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(6,7-dimethoxy-3,4-dihydro-1~{H}-isoquinolin-2-yl)-6-(3-methoxyphenyl)pyrimidin-2-amine, CALCIUM ION, ... | 著者 | Yang, J. | 登録日 | 2023-05-30 | 公開日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Structure-based design and synthesis of BML284 derivatives: A novel class of colchicine-site noncovalent tubulin degradation agents. Eur.J.Med.Chem., 268, 2024
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5XKF
| Crystal structure of T2R-TTL-MPC6827 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Wang, Y, Yang, J, Wang, T, Chen, L. | 登録日 | 2017-05-07 | 公開日 | 2018-04-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors To Be Published
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7LZ7
| Tubulin-RB3_SLD-TTL in complex with compound 5k | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(3,6-dimethyl[1,2]oxazolo[5,4-d]pyrimidin-4-yl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, CALCIUM ION, ... | 著者 | White, S.W, Yun, M. | 登録日 | 2021-03-09 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor. J.Med.Chem., 64, 2021
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7TQX
| CaKip3[2-482] - AMP-PNP in complex with a microtubule | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein, ... | 著者 | Benoit, M.P.M.H, Asenjo, A.B, Hunter, B, Allingham, J, Sosa, H. | 登録日 | 2022-01-27 | 公開日 | 2022-07-20 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape. Nat Commun, 13, 2022
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7DBB
| SSE in complex with tubulin | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-phenyl-3-(3,4,5-trimethoxyphenyl)-3,4-dihydropyrazole-2-carbothioamide, CALCIUM ION, ... | 著者 | Wu, C.Y, Wang, Y.X. | 登録日 | 2020-10-19 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.805 Å) | 主引用文献 | SSE in complex with tubulin To Be Published
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7XR1
| Crystal structure of T2R-TTL-3a complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloranyl-6-fluoranyl-N-(4-methoxyphenyl)-N-methyl-quinazolin-4-amine, CALCIUM ION, ... | 著者 | Lun, T, Wu, C.Y. | 登録日 | 2022-05-09 | 公開日 | 2023-05-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Crystal structure of T2R-TTL-3a complex To Be Published
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7DB9
| IC1 in complex with tubulin | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[(2,4,6-TRIMETHOXY-PHENYL)-METHYLENE]-INDOLIN-2-ONE, CALCIUM ION, ... | 著者 | Wu, C.Y, Wang, Y.X. | 登録日 | 2020-10-19 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.845 Å) | 主引用文献 | IC1 in complex with tubulin To Be Published
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7DAD
| EPD in complex with tubulin | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... | 著者 | Wang, Y, Wu, C. | 登録日 | 2020-10-16 | 公開日 | 2021-03-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | High-resolution X-ray structure of three microtubule-stabilizing agents in complex with tubulin provide a rationale for drug design. Biochem.Biophys.Res.Commun., 534, 2021
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6Y4N
| Structure of Tubulin Tyrosine Ligase in Complex with Tb116 | 分子名称: | (2~{R})-1-methylpiperidine-2-carboxylic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Gavrilyuk, J, Nocek, B, Rigol, S, Nicolaou, K.C, Stoll, V. | 登録日 | 2020-02-21 | 公開日 | 2021-03-31 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.852 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis. J.Org.Chem., 86, 2021
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6D88
| Tubulin-RB3_SLD-TTL in complex with compound 13f | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Kumar, G, Wang, Y, Li, W, White, S.W. | 登録日 | 2018-04-26 | 公開日 | 2018-09-12 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.853 Å) | 主引用文献 | Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities. J. Med. Chem., 61, 2018
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7X4N
| Crystal Structure of C. elegans kinesin-4 KLP-12 complexed with tubulin and DARPin | 分子名称: | DARPin, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Taguchi, S, Imasaki, T, Saijo-Hamano, Y, Sakai, N, Nitta, R. | 登録日 | 2022-03-03 | 公開日 | 2022-09-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | 主引用文献 | Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 -tubulin complex. Elife, 11, 2022
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1TVK
| The binding mode of epothilone A on a,b-tubulin by electron crystallography | 分子名称: | EPOTHILONE A, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Nettles, J.H, Li, H, Cornett, B, Krahn, J.M, Snyder, J.P, Downing, K.H. | 登録日 | 2004-06-29 | 公開日 | 2004-09-14 | 最終更新日 | 2023-08-23 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.89 Å) | 主引用文献 | The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography Science, 305, 2004
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5XIW
| Crystal structure of T2R-TTL-Colchicine complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Wang, Y, Yang, J, Wang, T, Chen, L. | 登録日 | 2017-04-27 | 公開日 | 2018-04-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin. J. Biol. Chem., 2018
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6X1C
| Tubulin-RB3_SLD-TTL in complex with compound 5j | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-chlorofuro[3,2-d]pyrimidin-4-yl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, CALCIUM ION, ... | 著者 | White, S.W, Yun, M. | 登録日 | 2020-05-18 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor. J.Med.Chem., 64, 2021
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6X1E
| Tubulin-RB3_SLD-TTL in complex with compound 5l | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, CALCIUM ION, ... | 著者 | White, S.W, Yun, M. | 登録日 | 2020-05-18 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor. J.Med.Chem., 64, 2021
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8V4L
| CCP5 in complex with microtubules class2 | 分子名称: | Cytosolic carboxypeptidase-like protein 5, GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, J, Zehr, E.A, Gruschus, J.M, Szyk, A, Liu, Y, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | 登録日 | 2023-11-29 | 公開日 | 2024-07-17 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Tubulin code eraser CCP5 binds branch glutamates by substrate deformation. Nature, 631, 2024
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7LZ8
| Tubulin-RB3_SLD-TTL in complex with compound 5t | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[2-(ethylamino)pyrido[3,2-d]pyrimidin-4-yl]-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, CALCIUM ION, ... | 著者 | White, S.W, Yun, M. | 登録日 | 2021-03-09 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | 主引用文献 | X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor. J.Med.Chem., 64, 2021
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5YLS
| Crystal structure of T2R-TTL-Y50 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, E-3-(3-azanyl-4-methoxy-phenyl)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)prop-2-en-1-one, ... | 著者 | Yang, J.H, Chen, L.J. | 登録日 | 2017-10-18 | 公開日 | 2018-04-11 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin. J. Biol. Chem., 293, 2018
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