6D88

Tubulin-RB3_SLD-TTL in complex with compound 13f

Summary for 6D88

• Entry DOI: 10.2210/pdb6d88/pdb
• Descriptor: Tubulin alpha-1B chain, [2-(1H-indol-3-yl)-1H-imidazol-4-yl](8-methoxy-1,4-benzodioxin-6-yl)methanone, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: microtubule inhibitor, colchicine, cancer, cell cycle
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 6
• Total formula weight: 265033.22

Authors

Kumar, G.,Wang, Y.,Li, W.,White, S.W. (deposition date: 2018-04-26, release date: 2018-09-12, Last modification date: 2024-03-13)

• Primary citation: Wang, Q.,Arnst, K.E.,Wang, Y.,Kumar, G.,Ma, D.,Chen, H.,Wu, Z.,Yang, J.,White, S.W.,Miller, D.D.,Li, W.; Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities.; J. Med. Chem., 61:7877-7891, 2018; PubMed: 30122035; DOI: 10.1021/acs.jmedchem.8b00827

Experimental method

X-RAY DIFFRACTION (2.853 Å)